DIAMIDE ANALOGS OF PHOSPHATIDYL CHOLINE AS POTENTIAL ANTI-AIDS AGENTS

被引：17

作者：

JIA, CH ^{[1
]}

HAINES, AH ^{[1
]}

机构：

[1] UNIV E ANGLIA,SCH CHEM SCI,NORWICH NR4 7TJ,NORFOLK,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 21期

关键词：

D O I：

10.1039/p19930002521

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acylation of 3-tetrahydropyran-2-yloxypropane-1,2-diamine with dodecanoyl chloride (lauroyl chloride) and hexadecanoyl chloride (palmitoyl chloride) followed by O-deprotection afforded racemic diamide analogues of 1,2-diglycerides which were converted by sequential treatment with 2-chloro-1,3,2-dioxaphospholan-2-one and trimethylamine into the corresponding diamide analogues of phosphatidyl choline. One of these compounds shows moderate anti-HIV activity.

引用

页码：2521 / 2523

页数：3

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