PARAMAGNETIC WATER PROTON RELAXATION ENHANCEMENT - FROM CONTRAST AGENTS IN MRI TO REAGENTS FOR QUANTITATIVE INVITRO ASSAYS

被引：16

作者：

AIME, S

BOTTA, M

ERMONDI, G

FASANO, M

TERRENO, E

机构：

[1] Dipartimento di Chimica Inorganica, Chimica Fisica e Chimica dei Materiali, Università degli Studi di Torino, 10125 Torino

来源：

MAGNETIC RESONANCE IMAGING | 1992年 / 10卷 / 05期

关键词：

PARAMAGNETIC RELAXATION; QUANTITATIVE ASSAYS; TRANSFERRIN; GLYCATED ALBUMIN;

D O I：

10.1016/0730-725X(92)90421-U

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The use of stable complexes of paramagnetic metal ions as probes in analytical applications of the NMR technique is discussed. Two examples are given that involve the determination of the total Fe3+ content of human serum transferrin (Tf) and the extent of glycation of human serum albumin (HSA). The method is based on the measurement of the longitudinal water proton relaxation times, conveniently altered following a selective chemical interaction between the substrate and the paramagnetic probe.

引用

页码：849 / 854

页数：6

共 17 条

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