INFLUENCE OF SLEEP ON GENIOGLOSSUS MUSCLE ACTIVATION BY NEGATIVE-PRESSURE IN NORMAL MEN

被引:160
作者
WHEATLEY, JR
MEZZANOTTE, WS
TANGEL, DJ
WHITE, DP
机构
[1] NATL JEWISH CTR IMMUNOL & RESP MED,DENVER,CO
[2] UNIV COLORADO,HLTH SCI CTR,DENVER,CO 80262
来源
AMERICAN REVIEW OF RESPIRATORY DISEASE | 1993年 / 148卷 / 03期
关键词
D O I
10.1164/ajrccm/148.3.597
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
An important mechanism controlling genioglossus (GG) muscle activity is the reflex response to negative airway pressure. We hypothesize that this reflex response may be lost during sleep and believe that this loss may be important in the pathogenesis of airway collapse during sleep. Thus, we determined the effect of non-rapid eye movement (NREM) sleep on the GG electromyogram (EMG) response to brief (0.2 to 0.6 s) episodes of negative pressure generation (NPG) in the upper airway of six normal subjects. Up to 100 NPGs (mean 58 +/- 12) were recorded both awake and during stable NREM sleep. During wakefulness, the change in GG moving time average EMG from basal to peak levels (during NPG) was 17.1 +/- 2.5 au (a 154 +/- 22% increase above basal levels). This response was markedly reduced during NREM sleep (2.7 +/- 1.2 au; p < 0.01). The latency of the GG EMG response was 53.8 +/- 11.5 ms during wakefulness (n = 6), but much longer during sleep (132.7 +/- 24.5 ms; n = 3; p < 0.03). We conclude that in normal subjects (1) the GG muscle responds to negative airway pressure by reflex activation during wakefulness, and (2) this reflex activation is reduced or lost during NREM sleep. We speculate that loss of this mechanism during sleep may contribute to pharyngeal collapse in obstructive apnea patients.
引用
收藏
页码:597 / 605
页数:9
相关论文
共 38 条
[1]   UPPER AIRWAY AND RESPIRATORY MUSCLE RESPONSES TO CONTINUOUS NEGATIVE AIRWAY PRESSURE [J].
ARONSON, RM ;
ONAL, E ;
CARLEY, DW ;
LOPATA, M .
JOURNAL OF APPLIED PHYSIOLOGY, 1989, 66 (03) :1373-1382
[2]  
Berardelli A, 1988, Adv Neurol, V50, P525
[3]   NEUROMUSCULAR MECHANISM MAINTAINING EXTRATHORACIC AIRWAY PATENCY [J].
BROUILLETTE, RT ;
THACH, BT .
JOURNAL OF APPLIED PHYSIOLOGY, 1979, 46 (04) :772-779
[4]  
GIAQUINTO S, 1964, Arch Ital Biol, V102, P245
[5]  
GRANIT R, 1952, Acta Physiol Scand, V27, P130
[6]  
HAPONIK EF, 1983, AM REV RESPIR DIS, V127, P221
[7]   DEPRESSION OF ELECTRICALLY INDUCED REFLEXES ( H-REFLEXES ) IN MAN DURING LOW VOLTAGE EEG SLEEP [J].
HODES, R ;
DEMENT, WC .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1964, 17 (06) :617-&
[8]   EVIDENCE FOR REFLEX UPPER AIRWAY DILATOR MUSCLE ACTIVATION BY SUDDEN NEGATIVE AIRWAY PRESSURE IN MAN [J].
HORNER, RL ;
INNES, JA ;
MURPHY, K ;
GUZ, A .
JOURNAL OF PHYSIOLOGY-LONDON, 1991, 436 :15-29
[9]   AFFERENT PATHWAY(S) FOR PHARYNGEAL DILATOR REFLEX TO NEGATIVE-PRESSURE IN MAN - A STUDY USING UPPER AIRWAY ANESTHESIA [J].
HORNER, RL ;
INNES, JA ;
HOLDEN, HB ;
GUZ, A .
JOURNAL OF PHYSIOLOGY-LONDON, 1991, 436 :31-44
[10]   MECHANICS OF THE RESPIRATORY SYSTEM AND BREATHING PATTERN DURING SLEEP IN NORMAL HUMANS [J].
HUDGEL, DW ;
MARTIN, RJ ;
JOHNSON, B ;
HILL, P .
JOURNAL OF APPLIED PHYSIOLOGY, 1984, 56 (01) :133-137