MAPPING OF BODY-WEIGHT LOCI ON MOUSE CHROMOSOME-X

被引：60

作者：

DRAGANI, TA ^{[1
]}

ZENG, ZB ^{[1
]}

CANZIAN, F ^{[1
]}

GARIBOLDI, M ^{[1
]}

GHILARDUCCI, MT ^{[1
]}

MANENTI, G ^{[1
]}

PIEROTTI, MA ^{[1
]}

机构：

[1] N CAROLINA STATE UNIV,DEPT STAT,RALEIGH,NC 27695

来源：

MAMMALIAN GENOME | 1995年 / 6卷 / 11期

关键词：

D O I：

10.1007/BF00539002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inheritance of overweight in humans appears to be under polygenic control. Study on the mouse model may help to determine candidate regions in human genome for the search of overweight genes. Inbred mouse strains showed wide variation in body weight and can provide an experimental model for the study of inheritance of overweight. By genetic linkage analysis, we report the mapping of two loci, named Bw1 and Bw2 (body weight 1 and 2), on Chromosome (Chr) X that strongly affect adult body weight in two interspecific testcross male populations (HSB and ASB) of mice. In addition, another locus, named Bw3, is also mapped on Chr X in ASB populations. These loci account for up to 24% of the phenotypic variation in both populations. Considering the conserved synteny between mouse and human Chr X, these results provide candidate regions on Chr X that can be tested for linkage with overweight in humans.

引用

页码：778 / 781

页数：4

共 26 条

[1] BORECKI IB, 1991, INT J OBESITY, V15, P763
[2] BORECKI IB, 1993, AM J HUM GENET, V53, P676
[3] COMPLICATIONS OF OBESITY
BRAY, GA
[J]. ANNALS OF INTERNAL MEDICINE, 1985, 103 (06) : 1052 - 1062
[4] MOUSE X-CHROMOSOME
BROWN, SDM
AVNER, P
BOYD, Y
CHAPMAN, V
RASTAN, S
SEFTON, L
THOMAS, JD
HERMAN, GE
[J]. MAMMALIAN GENOME, 1993, 4 : S269 - S281
[5] BURTON BT, 1985, INT J OBESITY, V9, P155
[6] GROWTH QUANTITATIVE TRAIT LOCI (QTL) ON MOUSE CHROMOSOME-10 IN A QUACKENBUSH-SWISS X C57BL/6J BACKCROSS
COLLINS, AC
MARTIN, ICA
KIRKPATRICK, BW
[J]. MAMMALIAN GENOME, 1993, 4 (08) : 454 - 458
[7] A GENETIC-LINKAGE MAP OF THE MOUSE - CURRENT APPLICATIONS AND FUTURE-PROSPECTS
COPELAND, NG
JENKINS, NA
GILBERT, DJ
EPPIG, JT
MALTAIS, LJ
MILLER, JC
DIETRICH, WF
WEAVER, A
LINCOLN, SE
STEEN, RG
STEIN, LD
NADEAU, JH
LANDER, ES
[J]. SCIENCE, 1993, 262 (5130) : 57 - 66
[8] DRAGANI TA, 1991, CANCER RES, V51, P6299
[9] MOLECULAR MAPPING OF OBESITY GENES
FRIEDMAN, JM
LEIBEL, RL
BAHARY, N
[J]. MAMMALIAN GENOME, 1991, 1 (03) : 130 - 144
[10] MORBID-OBESITY AND RELATED HEALTH RISKS
KRAL, JG
[J]. ANNALS OF INTERNAL MEDICINE, 1985, 103 (06) : 1043 - 1047

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