ENHANCED CYTOTOXICITY OF AMYLOID BETA-PEPTIDE BY A COMPLEMENT-DEPENDENT MECHANISM

被引：31

作者：

SCHULTZ, J

SCHALLER, J

MCKINLEY, M

BRADT, B

COOPER, N

MAY, P

ROGERS, J

机构：

[1] SUN HLTH RES INST, LJ ROBERTS CTR, SUN CITY, AZ 85372 USA

[2] Scripps Res Inst, DEPT IMMUNOL, LA JOLLA, CA 92037 USA

[3] ELI LILLY & CO, LILLY RES LABS, DIV CNS, INDIANAPOLIS, IN 46286 USA

来源：

NEUROSCIENCE LETTERS | 1994年 / 175卷 / 1-2期

关键词：

AMYLOID BETA-PEPTIDE; COMPLEMENT; INFLAMMATION; ALZHEIMERS DISEASE; CELL;

D O I：

10.1016/0304-3940(94)91088-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amyloid beta-peptide (A beta) has been shown to activate the classical complement pathway in vitro. Here, we demonstrate that this interaction is fully capable of killing cells and damaging cellular processes in mixed hippocampal cultures from embryonic day 18 rat fetuses. Lactic acid dehydrogenase (LDH) release and morphologic changes were used to evaluate toxicity.

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页码：99 / 102

页数：4

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