17-BETA-HYDROXYWORTMANNIN - A POTENT INHIBITOR OF BONE-RESORPTION AND PHOSPHATIDYLINOSITOL-3-KINASE

被引：16

作者：

DODGE, JA

BRYANT, HU

KIM, J

MATTER, WF

NORMAN, BH

SRINIVASAN, U

VLAHOS, CJ

SATO, M

机构：

[1] Lilly Research Laboratories Eli Lilly and Company, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 15期

关键词：

D O I：

10.1016/0960-894X(95)00291-Z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-function studies on the natural product wortmannin have identified a 17 beta-hydroxy derivative as a potent inhibitor of osteoclast function in both cell and animal models. Mechanistic studies indicate osteoclast differentiation is dramatically affected by this class of compounds. Interestingly, comparable potency trends for resorption and phosphatidylinositol-3-kinase inhibition were also observed.

引用

页码：1713 / 1718

页数：6

共 31 条

[1] SUPEROXIDE PRODUCTION BY HUMAN EOSINOPHILS CAN BE INHIBITED IN AN AGONIST-SELECTIVE MANNER
BACH, MK
BRASHLER, JR
PETZOLD, EN
SANDERS, ME
[J]. AGENTS AND ACTIONS, 1992, 35 (1-2): : 1 - 11
[2] INHIBITION OF THE PHAGOCYTOSIS-INDUCED RESPIRATORY BURST BY THE FUNGAL METABOLITE WORTMANNIN AND SOME ANALOGS
BAGGIOLINI, M
DEWALD, B
SCHNYDER, J
RUCH, W
COOPER, PH
PAYNE, TG
[J]. EXPERIMENTAL CELL RESEARCH, 1987, 169 (02) : 408 - 418
[3] RALOXIFENE (LY139481 HCL) PREVENTS BONE LOSS AND REDUCES SERUM-CHOLESTEROL WITHOUT CAUSING UTERINE HYPERTROPHY IN OVARIECTOMIZED RATS
BLACK, LJ
SATO, M
ROWLEY, ER
MAGEE, DE
BEKELE, A
WILLIAMS, DC
CULLINAN, GJ
BENDELE, R
KAUFFMAN, RF
BENSCH, WR
FROLIK, CA
TERMINE, JD
BRYANT, HU
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (01) : 63 - 69
[4] DEMETHOXYVIRIDIN AND WORTMANNIN BLOCK PHOSPHOLIPASE-C AND PHOSPHOLIPASE-D ACTIVATION IN THE HUMAN NEUTROPHIL
BONSER, RW
THOMPSON, NT
RANDALL, RW
TATESON, JE
SPACEY, GD
HODSON, HF
GARLAND, LG
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1991, 103 (01) : 1237 - 1241
[5] BRIAN PW, 1957, T BRIT MYCOL SOC, P365
[6] SYNTHETIC STUDIES ON WORTMANNIN AND 11-DESACETOXYWORTMANNIN
BROKA, CA
RUHLAND, B
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (18) : 4888 - 4894
[7] CLOSSE A, 1981, J MED CHEM, V24, P1466
[8] DEWALD B, 1988, J BIOL CHEM, V263, P16179
[9] BISPHOSPHONATES - PHARMACOLOGY AND USE IN THE TREATMENT OF TUMOR-INDUCED HYPERCALCEMIC AND METASTATIC BONE-DISEASE
FLEISCH, H
[J]. DRUGS, 1991, 42 (06) : 919 - 944
[10] ISOLATION AND STRUCTURAL ELUCIDATION OF 11-DEACETOXYWORTMANNIN
HAEFLIGE.W
HAUSER, D
[J]. HELVETICA CHIMICA ACTA, 1973, 56 (08) : 2901 - 2904

← 1 2 3 4 →