IL-3, IL-4, AND IL-6 ENHANCE IFN-GAMMA-DEPENDENT BONE-MARROW NATURAL SUPPRESSOR ACTIVITY

被引:23
作者
HOLDA, JH
MAIER, T
CLAMAN, HN
机构
[1] UNIV COLORADO, SCH MED, DEPT MED, DENVER, CO 80202 USA
[2] UNIV COLORADO, SCH MED, DEPT MICROBIOL IMMUNOL, DENVER, CO 80202 USA
关键词
D O I
10.1016/0008-8749(90)90099-D
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The ability of murine bone marrow (BM) natural suppressor (NS) cells to suppress a Con A proliferation assay was greatly enhanced by supernatant obtained from the T cell hybridoma D9C1.12.17. Of the lymphokines produced by this hybridoma, three were found to enhance suppression: interleukin-3 (IL-3), IL-4, and IL-6. These molecules enhanced suppression of both unirradiated and irradiated (2000 R) BM cells indicating that augmented suppression was not just due to proliferation of NS cells. The ability of all three of the lymphokines to enhance BM suppression could be blocked by anti-interferon-γ (IFN-γ) antibody. These results indicate that (1) NS cell activity is not radiosensitive and (2) that two signals may be required for maximal NS cell suppression, one being a lymphokine-mediated signal and the other IFN-γ. © 1990.
引用
收藏
页码:459 / 468
页数:10
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