THE FTF GENE ENCODING THE CELL-BOUND FRUCTOSYLTRANSFERASE OF STREPTOCOCCUS-SALIVARIUS ATCC 25975 IS PRECEDED BY AN INSERTION-SEQUENCE AND FOLLOWED BY FUR1 AND CLPP HOMOLOGS

被引：22

作者：

GIFFARD, PM ^{[1
]}

RATHSAM, C ^{[1
]}

KWAN, E ^{[1
]}

KWAN, DWL ^{[1
]}

BUNNY, KL ^{[1
]}

KOO, SP ^{[1
]}

JACQUES, NA ^{[1
]}

机构：

[1] INST DENT RES, 2 CHALMERS ST, SYDNEY, NSW 2010, AUSTRALIA

来源：

JOURNAL OF GENERAL MICROBIOLOGY | 1993年 / 139卷

关键词：

D O I：

10.1099/00221287-139-5-913

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Analysis of the region downstream of the ftf gene of Streptococcus salivarius led to the detection of two open reading frames (ORFs). The deduced amino acid sequences of these ORFs were homologous to proteins encoded by genes not previously described and/or sequenced in Gram-positive bacteria. The deduced amino acid sequence of the first of these (orf2) showed strong homology to the product of the FUR1 gene of Saccharomyces cerevisiae, which codes for a uracil phosphoribosyltransferase. The over-expression of the product of this gene appeared to be the source of the detrimental effect observed with phagemids carrying orf2 in Escherichia coli hosts. The deduced amino acid sequence of the second ORF (orf3) was homologous to the ClpP family of proteases. Examination of the upstream region of the ftf gene led to the discovery of a new insertion sequence-like element which has been designated IS1161.

引用

页码：913 / 920

页数：8

共 34 条

[1] GENETIC AND ANTIGENIC COMPARISON OF STREPTOCOCCUS-MUTANS FRUCTOSYLTRANSFERASE AND GLUCAN-BINDING PROTEIN
ADUSEOPOKU, J
GILPIN, ML
RUSSELL, RRB
[J]. FEMS MICROBIOLOGY LETTERS, 1989, 59 (03) : 279 - 282
[2] NUCLEOTIDE-SEQUENCE OF THE PROKARYOTIC MOBILE GENETIC ELEMENT IS30
DALRYMPLE, B
CASPERS, P
ARBER, W
[J]. EMBO JOURNAL, 1984, 3 (09) : 2145 - 2149
[3] CLONING AND SEQUENCING OF IS1086, AN ALCALIGENES-EUTROPHUS INSERTION ELEMENT RELATED TO IS30 AND IS4351
DONG, Q
SADOUK, A
VANDERLELIE, D
TAGHAVI, S
FERHAT, A
NUYTEN, JM
BORREMANS, B
MERGEAY, M
TOUSSAINT, A
[J]. JOURNAL OF BACTERIOLOGY, 1992, 174 (24) : 8133 - 8138
[4] FELSENSTEIN J, 1985, EVOLUTION, V39, P783, DOI 10.1111/j.1558-5646.1985.tb00420.x
[5] MOLECULAR CHARACTERIZATION OF A CLUSTER OF AT LEAST 2 GLUCOSYLTRANSFERASE GENES IN STREPTOCOCCUS-SALIVARIUS ATCC-25975
GIFFARD, PM
SIMPSON, CL
MILWARD, CP
JACQUES, NA
[J]. JOURNAL OF GENERAL MICROBIOLOGY, 1991, 137 : 2577 - 2593
[6] GENETICS OF PROTEOLYSIS IN ESCHERICHIA-COLI
GOTTESMAN, S
[J]. ANNUAL REVIEW OF GENETICS, 1989, 23 : 163 - 198
[7] CONSERVATION OF THE REGULATORY SUBUNIT FOR THE CLP ATP-DEPENDENT PROTEASE IN PROKARYOTES AND EUKARYOTES
GOTTESMAN, S
SQUIRES, C
PICHERSKY, E
CARRINGTON, M
HOBBS, M
MATTICK, JS
DALRYMPLE, B
KURAMITSU, H
SHIROZA, T
FOSTER, T
CLARK, WP
ROSS, B
SQUIRES, CL
MAURIZI, MR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (09) : 3513 - 3517
[8] SEQUENCE DIVERSITY AMONG RELATED GENES FOR RECOGNITION OF SPECIFIC TARGETS IN DNA-MOLECULES
GOUGH, JA
MURRAY, NE
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1983, 166 (01) : 1 - 19
[9] NUCLEOTIDE-SEQUENCE OF A WHEAT CHLOROPLAST GENE ENCODING THE PROTEOLYTIC SUBUNIT OF AN ATP-DEPENDENT PROTEASE
GRAY, JC
HIRD, SM
DYER, TA
[J]. PLANT MOLECULAR BIOLOGY, 1990, 15 (06) : 947 - 950
[10] HIGGINS DG, 1992, COMPUT APPL BIOSCI, V8, P189

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