MAGNETIZATION-TRANSFER AFFECTS THE PROTON CREATINE PHOSPHOCREATINE SIGNAL INTENSITY - IN-VIVO DEMONSTRATION IN THE RAT-BRAIN

被引：47

作者：

DREHER, W

NORRIS, DG

LEIBFRITZ, D

机构：

来源：

MAGNETIC RESONANCE IN MEDICINE | 1994年 / 31卷 / 01期

关键词：

PROTON NMR SPECTROSCOPY; MAGNETIZATION TRANSFER; CREATINE; BRAIN;

D O I：

10.1002/mrm.1910310114

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The effect of off-resonance preirradiation on proton spectra acquired from the healthy rat brain at 4.7 T is examined using a PRESS sequence. The creatine/phosphocreatine (Cr/PCr) signal at 3.0 ppm decreases in signal intensity for offset frequencies between +/-10 kHz. This cannot be explained by RF bleedover, but is attributed to magnetization transfer between two pools of Cr/PCr, one with a long T-2 relaxation time giving the observed NMR signal, the other corresponding to a broad resonance line being completely or partially saturated by off-resonance preirradiation. Possible interpretations of these results are discussed.

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页码：81 / 84

页数：4

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