INFLUENCE OF PROTEIN-MALNUTRITION ON TERATOGENICITY OF ACETYLSALICYLIC-ACID IN RATS

被引：6

作者：

HAMED, MR ^{[1
]}

ALASSY, YS ^{[1
]}

EZZELDIN, E ^{[1
]}

机构：

[1] CAIRO UNIV,FAC SCI,CAIRO,EGYPT

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1994年 / 13卷 / 02期

关键词：

D O I：

10.1177/096032719401300204

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The effect of protein malnutrition (PM) on the embryotoxicity and teratogenicity of aspirin in rats has been studied. Protein malnourishment was produced from Days 7 to 21 of gestation by limiting the casein content of the diet to 5% in comparison to 20% for the normal animals, Six dose levels of aspirin (50-175 mg kg(-1)) were administered p.o. from Days 8 to 11 of pregnancy. Aspirin from 75 mg kg(-1) d(-1) induced growth retardation, embryolethality and teratogenicity, as shown by external, skeletal and visceral malformations. All these effects were potentiated by protein malnutrition.

引用

页码：83 / 88

页数：6

共 20 条

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