MAPPING OF CROSS-REACTING AND SEROTYPE-SPECIFIC EPITOPES ON THE VP3 STRUCTURAL PROTEIN OF THE INFECTIOUS BURSAL DISEASE VIRUS (IBDV) - BRIEF REPORT

被引：16

作者：

MAHARDIKA, GNK

BECHT, H

机构：

[1] Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen

来源：

ARCHIVES OF VIROLOGY | 1995年 / 140卷 / 04期

关键词：

D O I：

10.1007/BF01309964

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The binding sites of a panel of monoclonal antibodies cross-reacting with the structural protein VP3 of the two serotypes of the infectious bursal disease virus (IBDV) could be mapped to four segments of the VP3 gene. Two of these antigenic domains also carry epitopes which are specific for one serotype only. Formation of the common or type-specific epitopes is in agreement with homologous or mismatching amino acid sequences yielding hydrophilic segments on the VP3 polypeptide. These antigenic patterns obtained by immunoblotting could be verified by a competitive ELISA.

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页码：765 / 774

页数：10

相关论文

共 21 条

[1] DELETION MAPPING AND EXPRESSION IN ESCHERICHIA-COLI OF THE LARGE GENOMIC SEGMENT OF A BIRNAVIRUS [J].

AZAD, AA ;

JAGADISH, MN ;

BROWN, MA ;

HUDSON, PJ .

VIROLOGY, 1987, 161 (01) :145-152

[2] THE CHARACTERIZATION AND MOLECULAR-CLONING OF THE DOUBLE-STRANDED-RNA GENOME OF AN AUSTRALIAN STRAIN OF INFECTIOUS BURSAL DISEASE VIRUS [J].

AZAD, AA ;

BARRETT, SA ;

FAHEY, KJ .

VIROLOGY, 1985, 143 (01) :35-44

[3] A COMPARISON OF THE SEQUENCES OF SEGMENT-A OF 4 INFECTIOUS BURSAL DISEASE VIRUS-STRAINS AND IDENTIFICATION OF A VARIABLE REGION IN VP2 [J].

BAYLISS, CD ;

SPIES, U ;

SHAW, K ;

PETERS, RW ;

PAPAGEORGIOU, A ;

MULLER, H ;

BOURSNELL, MEG .

JOURNAL OF GENERAL VIROLOGY, 1990, 71 :1303-1312

[4] COMPARATIVE STUDIES ON STRUCTURAL AND ANTIGENIC PROPERTIES OF 2 SEROTYPES OF INFECTIOUS BURSAL DISEASE VIRUS [J].

BECHT, H ;

MULLER, H ;

MULLER, HK .

JOURNAL OF GENERAL VIROLOGY, 1988, 69 :631-640

[5]

Becht H, 1980, Curr Top Microbiol Immunol, V90, P107

[6] THE ISOLATION OF INFECTIOUS BURSAL DISEASE VIRUS FROM TURKEYS IN ENGLAND [J].

CHETTLE, NJ ;

EDDY, RK ;

WYETH, PJ .

BRITISH VETERINARY JOURNAL, 1985, 141 (02) :141-145

[7] BIOPHYSICAL AND BIOCHEMICAL CHARACTERIZATION OF 5 ANIMAL VIRUSES WITH BISEGMENTED DOUBLE-STRANDED-RNA GENOMES [J].

DOBOS, P ;

HILL, BJ ;

HALLETT, R ;

KELLS, DTC ;

BECHT, H ;

TENINGES, D .

JOURNAL OF VIROLOGY, 1979, 32 (02) :593-605

[8] SEQUENCE-ANALYSIS AND EXPRESSION OF THE HOST-PROTECTIVE IMMUNOGEN-VP2 OF A VARIANT STRAIN OF INFECTIOUS BURSAL DISEASE VIRUS WHICH CAN CIRCUMVENT VACCINATION WITH STANDARD TYPE-I STRAINS [J].

HEINE, HG ;

HARITOU, M ;

FAILLA, P ;

FAHEY, K ;

AZAD, A .

JOURNAL OF GENERAL VIROLOGY, 1991, 72 :1835-1843

[9] GENOMIC STRUCTURE OF THE LARGE RNA SEGMENT OF INFECTIOUS BURSAL DISEASE VIRUS [J].

HUDSON, PJ ;

MCKERN, NM ;

POWER, BE ;

AZAD, AA .

NUCLEIC ACIDS RESEARCH, 1986, 14 (12) :5001-5012

[10]

JACKWOOD DJ, 1982, AVIAN DIS, V26, P971