MECHANISMS OF PROTECTION BY OMEPRAZOLE AGAINST EXPERIMENTAL GASTRIC-MUCOSAL DAMAGE IN RATS

被引:24
作者
BLANDIZZI, C
GHERARDI, G
MARVEGGIO, C
NATALE, G
CARIGNANI, D
DELTACCA, M
机构
[1] UNIV PISA,SCH MED & DENT,INST MED PHARMACOL,I-56126 PISA,ITALY
[2] CIVIL HOSP SONDRIO,DEPT PATHOL,SONDRIO,ITALY
关键词
ETHANOL; GASTRIC ACID SECRETION; GASTRIC DAMAGE; GASTRIC MUCUS; GASTRIC PROTECTION; MISOPROSTOL; OMEPRAZOLE; RANITIDINE; RAT;
D O I
10.1159/000201247
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
In the present study, the protective effect of omeprazole on gastric mucosa injury induced by ethanol . HCl in rats and the putative mechanisms involved in this action were investigated. Misoprostol and ranitidine were used as reference drugs. The morphometric analysis of histological sections showed that omeprazole caused a significant reduction of mucosal necrotic damage, this effect being associated with a mraked increase in Alcian blue recovery from gastric bound mucus. In addition, omeprazole elicited a significant inhibition of gastric acid secretion from pylorus-ligated rats. Misoprostol exerted similar effects to those obtaine with omeprazole, even if the Alcian blue recovery and the acid output were affected to a lesser extent. By contrast, ranitidine failed to influence both the mucosal damage and the Alcian blue recovery, while it exerted a marked inhibition on acid secretion. The present results indicate that omeprazole is effective in protecting gastric mucosa from necrotic damage induced by ethanol . HCl and suggest that an enhancement of gastric mucus barrier may account for this protective action.
引用
收藏
页码:220 / 229
页数:10
相关论文
共 27 条
[1]   MISOPROSTOL PRECLINICAL PHARMACOLOGY [J].
BAUER, RF .
DIGESTIVE DISEASES AND SCIENCES, 1985, 30 (11) :S118-S125
[2]   RANITIDINE - A REVIEW OF ITS PHARMACOLOGY AND THERAPEUTIC USE IN PEPTIC-ULCER DISEASE AND OTHER ALLIED DISEASES [J].
BROGDEN, RN ;
CARMINE, AA ;
HEEL, RC ;
SPEIGHT, TM ;
AVERY, GS .
DRUGS, 1982, 24 (04) :267-303
[3]   OMEPRAZOLE - A PRELIMINARY REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC POTENTIAL IN PEPTIC-ULCER DISEASE AND ZOLLINGER-ELLISON SYNDROME [J].
CLISSOLD, SP ;
CAMPOLIRICHARDS, DM .
DRUGS, 1986, 32 (01) :15-47
[4]  
CORNE SJ, 1974, J PHYSIOL-LONDON, V242, pP116
[5]   EFFECTS OF MORPHINE ON GASTRIC-ULCERATION, BARRIER MUCUS AND ACID-SECRETION IN PYLORUS-LIGATED RATS [J].
DELTACCA, M ;
BERNARDINI, C ;
CORSANO, E ;
SOLDANI, G ;
ROZE, C .
PHARMACOLOGY, 1987, 35 (03) :174-180
[6]   SUBSTITUTED BENZIMIDAZOLES INHIBIT GASTRIC-ACID SECRETION BY BLOCKING (H++K+)ATPASE [J].
FELLENIUS, E ;
BERGLINDH, T ;
SACHS, G ;
OLBE, L ;
ELANDER, B ;
SJOSTRAND, SE ;
WALLMARK, B .
NATURE, 1981, 290 (5802) :159-161
[7]   EFFECT OF OMEPRAZOLE ON EICOSANOID FORMATION IN AND RELEASE FROM GUINEA-PIG GASTRIC-MUCOSAL CELLS [J].
HELL, M ;
SEWING, KF .
BRITISH JOURNAL OF PHARMACOLOGY, 1987, 91 (01) :69-75
[8]   MORPHOLOGY OF RAT GASTRIC-MUCOSAL DAMAGE, DEFENSE, AND RESTITUTION IN THE PRESENCE OF LUMINAL ETHANOL [J].
ITO, S ;
LACY, ER .
GASTROENTEROLOGY, 1985, 88 (01) :250-260
[9]   PROTECTIVE ACTION OF OMEPRAZOLE, A BENZIMIDAZOLE DERIVATIVE, ON GASTRIC-MUCOSAL DAMAGE BY ASPIRIN AND ETHANOL IN RATS [J].
KONTUREK, SJ ;
BRZOZOWSKI, T ;
RADECKI, T .
DIGESTION, 1983, 27 (03) :159-164
[10]  
KONTUREK SJ, 1984, GASTROENTEROLOGY, V86, P71