PHARMACOKINETIC AND PHARMACODYNAMIC EFFECTS OF A SINGLE NOCTURNAL DOSE OF ALPRAZOLAM

被引：6

作者：

NORMAN, TR

BURROWS, GD

MCINTYRE, IM

机构：

[1] Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, VIC

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 1990年 / 5卷 / 02期

关键词：

D O I：

10.1097/00004850-199004000-00005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Six healthy volunteers participated in a study of the pharmacokinetic and psychomotor effects of a single dose of 2 mg of alprazolam compared to placebo when given at night. Alprazolam reached a maximum concentration in the plasma between 0-5 and 2-5 h after the dose. It was extensively distributed to the tissues as shown by the large apparent volume of distribution (1·42 1/kg) and slowly eliminated (t½ = 13·7 h). Significant impairment of choice reaction time occurred 1 and 11 h after the dose of alprazolam compared to placebo Critical flicker fusion was also impaired after alprazolam but the difference from the placebo administration did not reach significance. © 1990 CNS (Clinical Neuroscience) Publishers.

引用

页码：111 / 117

页数：7

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