REACTIONS OF 2'-DEOXY-2'-HALOURIDINES AND O(2),2'-CYCLOURIDINE WITH LITHIUM DIALKYLAMIDES - FORMATION OF 1',2'-UNSATURATED DERIVATIVES

被引：7

作者：

KITTAKA, A ^{[1
]}

TANAKA, H ^{[1
]}

MIYASAKA, T ^{[1
]}

YAMAGUCHI, K ^{[1
]}

机构：

[1] SHOWA UNIV,SCH PHARMACEUT SCI,HATANODAI 1-5-8,SHINAGAWA KU,TOKYO 142,JAPAN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 01期

关键词：

D O I：

10.1080/07328319208021151

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment of 2'-deoxy-2'-halouridine derivatives with lithium diisopropylamide (LDA) resulted in partial formation of the 1',2'-unsaturated nucleosides, no lithiation being observed in the base moiety of the recovered starting material. Reactions of an O2,2'-cyclouridine derivative with LDA or lithium 2,2,6,6-tetramethyl-piperidide (LTMP) were also examined.

引用

页码：37 / 47

页数：11

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