GLYCOSAMINOGLYCAN PROTEIN INTERACTIONS - A QUESTION OF SPECIFICITY

被引：133

作者：

SPILLMANN, D

LINDAHL, U

机构：

[1] Dorothe Spillman and Ulf Lindahl, Department of Medical and Physiology Chemistry, University of Uppsala, S-751 23 Uppsala

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 05期

关键词：

D O I：

10.1016/S0959-440X(94)90165-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycosaminoglycans, particularly of the heparin/heparan sulphate type, bind proteins and influence their biological properties. Attempts to define a glycosaminoglycan-binding polypeptide 'consensus sequence' have revealed certain common topological patterns involving basic amino acid residues. Different heparan sulphate species appear to express specific binding regions for different proteins, most of which also bind heparin in a seemingly 'non-specific' manner.

引用

页码：677 / 682

页数：6

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