DIFFUSE REFLECTANCE INFRARED FOURIER-TRANSFORM SPECTROSCOPY FOR THE QUANTITATIVE-ANALYSIS OF MIXTURES OF POLYMORPHS

被引：38

作者：

HARTAUER, KJ ^{[1
]}

MILLER, ES ^{[1
]}

GUILLORY, JK ^{[1
]}

机构：

[1] UNIV IOWA,COLL PHARM,IOWA CITY,IA 52242

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 85卷 / 1-3期

关键词：

FOURIER TRANSFORM INFRARED SPECTROSCOPY; DIFFUSE REFLECTANCE; POLYMORPHISM; SULFAMETHOXAZOLE; QUANTITATIVE ANALYSIS; MULTICOMPONENT ANALYSIS; PARTIAL LEAST-SQUARES;

D O I：

10.1016/0378-5173(92)90145-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Binary mixtures of sulfamethoxazole polymorphs were analyzed using diffuse reflectance infrared Fourier transform spectroscopy. A partial least-squares method was utilized for quantitative prediction from the overlapping, FT-IR spectra. The phase composition for a set of independent validation samples was predicted to within 4% of the theoretical values in all cases. The calibration model was valid over a 4 week testing period.

引用

页码：163 / 174

页数：12

共 19 条

[1] ANGULAR-DEPENDENCE OF DIFFUSE REFLECTANCE INFRARED-SPECTRA .3. LINEARITY OF KUBELKA-MUNK PLOTS [J].