IDENTIFICATION OF A TOXR-ACTIVATED GENE, TAGE, THAT LIES WITHIN THE ACCESSORY COLONIZATION FACTOR GENE-CLUSTER OF VIBRIO-CHOLERAE-O395

被引：15

作者：

KOVACH, ME ^{[1
]}

HUGHES, KJ ^{[1
]}

EVERISS, KD ^{[1
]}

PETERSON, KM ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV, MED CTR, DEPT MICROBIOL & IMMUNOL, SHREVEPORT, LA 71130 USA

来源：

GENE | 1994年 / 148卷 / 01期

关键词：

T7 RNA POLYMERASE; TOXR REGULON; ENDOPEPTIDASE; LYSOSTAPHIN; STAPHYLOCOCCUS;

D O I：

10.1016/0378-1119(94)90239-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The nucleotide (nt) sequence has been determined for a Vibrio cholerae ToxR-activated gene designated tagE that is located within a cluster of genes required for efficient intestinal colonization. The tagE gene encompasses 909 nt and is predicted to encode a 303-amino-acid (aa) protein with an estimated molecular mass of 34 468 Da. Computer-assisted similarity searches revealed that TagE possesses aa sequence similarity with Escherichia coli OrfU and staphylococcus simulans lysostaphin, two proteins that are involved in cell-wall biosynthesis and peptidoglycan degradation, respectively. The role, if any, that TagE plays in the accessory colonization factor phenotype is currently under investigation.

引用

页码：91 / 95

页数：5

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