TRIPLE HELIX BINDING OF OLIGODEOXYRIBONUCLEOTIDES CONTAINING 8-OXO-2'-DEOXYADENOSINE

被引：23

作者：

DAVISON, EC ^{[1
]}

JOHNSSON, K ^{[1
]}

机构：

[1] SWISS FED INST TECHNOL,ORGAN CHEM LAB,CH-8092 ZURICH,SWITZERLAND

来源：

NUCLEOSIDES & NUCLEOTIDES | 1993年 / 12卷 / 02期

关键词：

D O I：

10.1080/07328319308021209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Formation of a triple helix between an oligodeoxyribonucleotide containing 8-oxo-2'-deoxyadenosine and a DNA duplex target was studied as a function of pH. Above pH 7.4, the triple helix with the 8-oxo-2-deoxyadenosine was more stable than the complex with an analogous oligodeoxyribonucleotide containing deoxycytidine instead of 8-oxo-2'-deoxyadenosine.

引用

页码：237 / 243

页数：7

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