EFFECTS OF PHOSPHONYLMETHOXYALKYL DERIVATIVES STUDIED WITH A MURINE MODEL FOR ABORTION INDUCED BY EQUINE HERPESVIRUS-1

被引：11

作者：

AWAN, AR

FIELD, HJ

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 11期

关键词：

D O I：

10.1128/AAC.37.11.2478

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) were tested in a mouse model for equine herpesvirus 1-induced abortion. HPMPA, given twice daily, reduced virus replication, but the compound was embryotoxic. A single dose of HPMPC, however, reduced the incidence of abortion and transfer of virus to the fetuses while producing no obvious toxic effects.

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页码：2478 / 2482

页数：5

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