Pharmacological blood-brain barrier modification for selective drug delivery

被引：47

作者：

Cloughesy, TF ^{[1
]}

Black, KL ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED,UCLA NEUROONCOL PROGRAM,JONSSON CANC CTR, UCLA DIV NEUROSURG, LOS ANGELES, CA 90024 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 1995年 / 26卷 / 02期

关键词：

blood-brain barrier; drug delivery; leukotrienes; bradykinin; histamine; brain tumors;

D O I：

10.1007/BF01060218

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vasoactive agents have been identified through studies of peritumoral edema and effects on systemic capillaries. Abnormal blood-brain barrier or blood-tumor barrier can develop transient increases in permeability with the intraarterial delivery of vasoactive agents. Normal blood-brain barrier resists the effects of these compounds because of a biochemical barrier that may inactivate or become inert to vasoactive agents. Vasoactive compounds, including leukotrienes, bradykinin, and histamine appear to selectively increase permeability in abnormal brain capillaries. Intracarotid infusion of leukotrienes, bradykinin, and other vasoactive agents can increase drug delivery to diseased tissue.

引用

页码：125 / 132

页数：8

共 40 条

[21] EXVIVO RELEASE OF EICOSANOID FROM HUMAN BRAIN-TISSUE - ITS RELEVANCE IN THE DEVELOPMENT OF BRAIN EDEMA [J].