A CONTROLLED TRIAL EVALUATION OF 3 ORAL DOSAGES OF MOXIDECTIN AGAINST EQUINE PARASITES

被引：20

作者：

BELLO, TR

LANINGHAM, JET

机构：

[1] Sandhill Equine Center, Southern Pines, North Carolina, 28374

[2] Pinehurst Pathology Center, Inc., Moore Regional Hospital, Pinehurst, North Carolina, 28374

来源：

JOURNAL OF EQUINE VETERINARY SCIENCE | 1994年 / 14卷 / 09期

关键词：

D O I：

10.1016/S0737-0806(06)81977-5

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A controlled trial was performed to titrate the antiparasitic dosage of moxidectin in 40 mixed-breed ponies naturally infected with Strongylus vulgaris, and/or S. edentatus, and small strongyle species, as determined by parasitic egg and larval counts of feces. Moxidectin was given orally at 0, 0.3, 0.4 and 0.5 mg/kg of body weight in a gel vehicle. All ponies were euthanized and necropsied at 14 days after treatment. Strongylus vulgaris, S. edentatus, small strongyle species, Onchocerca cervicalis microfilariae, Habronema muscae, Oxyuris equi larvae, and Gasterophilus species were eliminated in response to all doses of moxidectin. Anoplocephala spp. were not affected by any dose. There were not sufficient numbers of Trichostrongylus axei, Draschia megastoma, Parascaris equorum, or mature Oxyuris equi in the ponies to evaluate the effectiveness of moxidectin against them. All dosage levels of moxidectin produced a profound reduction in the extent of intestinal inflammation. Moxidectin was highly effective in reducing the numbers of coiled strongyle larvae and larvae in nodules in the cecal and colonic mucosa. There appeared to be an inverse relationship between age of pony and the extent of reduction in intestinal inflammation in response to moxidectin treatment. No adverse effects were attributable to moxidectin treatment.

引用

页码：483 / 488

页数：6

共 11 条

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