THE ROLE OF HYPERGLYCEMIA-INDUCED ALTERATIONS OF ANTITHROMBIN-III AND FACTOR-X ACTIVATION IN THE THROMBIN HYPERACTIVITY OF DIABETES-MELLITUS

被引：22

作者：

CERIELLO, A ^{[1
]}

QUATRARO, A ^{[1
]}

MARCHI, E ^{[1
]}

BARBANTI, M ^{[1
]}

DELLORUSSO, P ^{[1
]}

LEFEBVRE, P ^{[1
]}

GIUGLIANO, D ^{[1
]}

机构：

[1] NAPLES UNIV,FAC MED 1,CATTEDRA DIABETOL & DIETOTERAPIA,I-80138 NAPLES,ITALY

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 04期

关键词：

Antithrombin III; Diabetes; Factor X; Hypercoagulability; Hyperglycaemia;

D O I：

10.1111/j.1464-5491.1990.tb01402.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Factor X concentration and factor X activation, antithrombin III anti‐Xa activity and plasma concentration, and fibrinopeptide A were measured in 20 diabetic patients and 20 normal subjects. Although factor X activation (81.3 ± 2.2 vs 97.3 ± 2.1 %, p < 0.01; mean ± SE) and antithrombin III activity (76.5 ± 2.2 vs 96.3 ± 1.8 %, p < 0.01) were reduced in the diabetic patients, fibrinopeptide A concentration was increased (3.7 ± 0.4 vs 1.7 ± 0.2 ng ml−1, p < 0.01). The ratio of factor X activation to antithrombin III anti‐factor Xa activity was increased in the diabetic patients (1.10 ± 0.01 vs 1.01 ± 0.02, p < 0.01). Induced hyperglycaemia was able to mimic all these abnormalities, without changing factor X or antithrombin III concentration. The results suggest that in vivo hyperglycaemia produces a decrease of factor X activation, but at the same time increases fibrinopeptide A formation due to a greater decrease of antithrombin III anti‐Xa activity. 1990 Diabetes UK

引用

页码：343 / 348

页数：6

共 15 条

[1] Yin ET, Wessler S., Stoll P., Biological properties of the naturally occurring plasma inhibitor to activated factor X, J Biol Chem, 246, pp. 3703-3711, (1971)
[2] Jones RL, Peterson CM., The fluid phase of coagulation and the accelerated atherosclerosis of diabetes mellitus, Diabetes, 30, pp. 33-38, (1981)
[3] Ostermann H., Van de Loo J., Factors of the hemostatic system in diabetic patients. A survey of controlled study, Haemostasis, 16, pp. 386-416, (1986)
[4] Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance, Diabetes, 28, pp. 1039-1057, (1979)
[5] Cerasi E., Luft R., ‘What is inherited ‐ what is added?’ Hypothesis for the pathogenesis of diabetes mellitus, Diabetes, 16, pp. 615-627, (1967)
[6] Odegard OR, Lie H., Abildgaard U., Antifactor Xa activity measured with amidolytic methods, Haemostasis, 5, pp. 265-275, (1976)
[7] Muntean WE, Borkenstein MH, Haas J., Elevation of factor VIII coagulant activity over factor VIII coagulant antigen in diabetic children without vascular disease, Diabetes, 34, pp. 140-144, (1985)
[8] Ceriello A., Giugliano D., Quatraro A., Et al., Blood glucose may condition factor VII levels in diabetic and normal subjects, Diabetologia, 31, pp. 889-891, (1988)
[9] Jones RL., Fibrinopeptide A in diabetes mellitus: relation to levels of blood glucose, fibrinogen disappearance, and hemodynamic changes, Diabetes, 34, pp. 836-843, (1985)
[10] Ceriello A., Giugliano D., Quatraro A., Et al., Hyperglycemia may determine fibrinopeptide A plasma level increase in humans, Metabolism, 38, pp. 1162-1163, (1989)

← 1 2 →