GLYCOGENOLYTIC EFFECT OF PANCREASTATIN IN THE RAT

被引：48

作者：

SANCHEZ, V ^{[1
]}

CALVO, JR ^{[1
]}

GOBERNA, R ^{[1
]}

机构：

[1] UNIV SEVILLA,SCH MED,DEPT MED BIOCHEM & MOLEC BIOL,AUDA SANCHEZ PIZJUAN 4,E-41009 SEVILLE,SPAIN

来源：

BIOSCIENCE REPORTS | 1990年 / 10卷 / 01期

关键词：

glycogen; pancreastatin;

D O I：

10.1007/BF01116856

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pancreastatin is a novel 49-amino acid peptide with a C-terminal glycine amide. The peptide was isolated from porcine pancreatic extracts and shows a structural similarity to chromogranin A. The effect of synthetic porcine pancreastatin on blood glucose levels and hepatic glycogen content was investigated in rats in vivo. Pancreastatin (300 pmol/kg) produced a time-dependent decrease in glycogen content of liver and a slight hyperglycemia. Basal plasma insulin and glucagon levels were not modified by pancreastatin. We suggest that pancreastatin could play a biological role in the glucose metabolism through a glycogenolytic effect. © 1990 Plenum Publishing Corporation.

引用

页码：87 / 91

页数：5

共 15 条

[1] PANCREASTATIN INHIBITS INSULIN-SECRETION AND STIMULATES GLUCAGON-SECRETION IN MICE [J].

AHREN, B ;

LINDSKOG, S ;

TATEMOTO, K ;

EFENDIC, S .

DIABETES, 1988, 37 (03) :281-285

[2]

EFENDIC S, 1987, P NATL ACAD SCI USA, V42, P1361

[3]

EIDEN LE, 1987, NATURE, V325, P325

[4]

ELMAGHRABI MR, 1982, J BIOL CHEM, V257, P7603

[5] EFFECT OF PANCREASTATIN ON PANCREATIC ENDOCRINE FUNCTION IN THE CONSCIOUS RAT [J].

FUNAKOSHI, A ;

MIYASAKA, K ;

KITANI, K ;

TATEMOTO, K .

REGULATORY PEPTIDES, 1989, 24 (03) :225-231

[6] PANCREASTATIN, A NOVEL NEUROPEPTIDE, IS WIDELY DISTRIBUTED THROUGHOUT PORCINE BRAIN, PITUITARY, SPINAL-CORD AND DORSAL-ROOT GANGLIA [J].

GIBSON, SJ ;

KAR, S ;

BALLESTA, J ;

STEEL, J ;

BRETHERTONWATT, DG ;

GHATEI, MA ;

VALENTINO, KL ;

TATEMOTO, K ;

BLOOM, SR ;

POLAK, JM .

REGULATORY PEPTIDES, 1987, 18 (5-6) :376-376

[7]

GRUBE D, 1986, HISTOCHEMISTRY, V85, P19

[8] CHROMOGRANIN-A AND PANCREASTATIN [J].

HUTTNER, WB ;

BENEDUM, UM .

NATURE, 1987, 325 (6102) :305-305

[9] GALANIN AND PANCREASTATIN INHIBIT STIMULATED INSULIN-SECRETION IN THE MOUSE - COMPARISON OF EFFECTS [J].

LINDSKOG, S ;

AHREN, B .

HORMONE RESEARCH, 1988, 29 (5-6) :237-240

[10] CHROMOGRANIN - WIDESPREAD IMMUNOREACTIVITY IN POLYPEPTIDE HORMONE PRODUCING TISSUES AND IN SERUM [J].

OCONNOR, DT .

REGULATORY PEPTIDES, 1983, 6 (03) :263-280

← 1 2 →