SYNTHESIS OF NEW ACROMELIC ACID CONGENERS - NOVEL NEUROEXCITATORY AMINO-ACIDS ACTING ON GLUTAMATE RECEPTOR

被引：61

作者：

HASHIMOTO, K ^{[1
]}

SHIRAHAMA, H ^{[1
]}

机构：

[1] HOKKAIDO UNIV, FAC SCI, DEPT CHEM, SAPPORO, HOKKAIDO 060, JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(00)78802-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general synthetic method of acromelic acid congeners was developed. Various C4-substituents of this family was introduced by the substitution reaction of the corresponding tosylate with diaryl copper lithium. Phenyl derivative 11 showed comparable excitatory activity with kainic acid, and o-anisyl derivative 12 had most potent activity in this family.

引用

页码：2625 / 2628

页数：4

共 23 条

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