RESIDUES OF THE BETA-AGONIST CLENBUTEROL IN TISSUES OF MEDICATED FARM-ANIMALS

被引：72

作者：

ELLIOTT, CT

MCCAUGHEY, WJ

SHORTT, HD

机构：

[1] Residue Laboratory, Veterinary Sciences Division, Belfast, BT4 3SD, Stoney Road

来源：

FOOD ADDITIVES AND CONTAMINANTS | 1993年 / 10卷 / 02期

关键词：

BETA-AGONIST; CLENBUTEROL; PHARMACOKINETICS; ASSAY;

D O I：

10.1080/02652039309374145

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Reports of the illegal use of clenbuterol as a growth promotant prompted the development of a competitive enzyme immunoassay for this drug. This procedure was utilized to study the elimination of clenbuterol from tissues in sheep medicated with both therapeutic and growth-promoting doses of the drug. The results indicated that prior to removal of medication clenbuterol was widely distributed throughout the animal tissues. However as the withdrawal periods increased fluid targets such as urine and bile became less effective at detecting clenbuterol usage. At both therapeutic and growth-enhancing concentrations of clenbuterol liver samples remained positive up to the maximum withdrawal time given in this experiment (15 days). Concentrations of clenbuterol likely to cause food poisoning (> 100 ng/g) were only detected in liver samples taken prior to the removal of medication. The highest recorded concentration of clenbuterol in muscle was 22.5 ng/g.

引用

页码：231 / 244

页数：14

共 19 条

[1] Adams H.R., New perspectives in cardiopulmonary therapeutics. Receptor selective adrenergic drugs, Journal of the American Veterinary Medical Association, 18, pp. 966-974, (1984)
[2] Allen P., Quirke J.F., Tarrent P.V., Effects of CIM on the growth, food efficiency and carcass quality of Friesian cattle, Beta-Agonists and Their Effects on Animal Growth and Carcass Quality, pp. 83-92, (1987)
[3] Anon, Statutory Rules of Northern Ireland. Animals, Meat and Meat Products (Examination for Residues and Maximum Residue Limits) Regulations, 39, (1992)
[4] Baker P.K., Liernan J.A., Derivatives for Enhancing the Growth Rate of Meat Producing Animals and Improving the Efficiency of Feed Utilisation, 4, (1983)
[5] Baker P.K., Dalrymple R.H., Ingle D.L., Ricks C.A., Use of a beta-adrenergic agonist to alter muscle and fat deposition in lambs, Journal of Animal Science, 59, pp. 1256-1261, (1984)
[6] Blanchflower W.J., Kennedy D.G., A rapid screening procedure for the detection and quantitation of clenbuterol in bovine urine using thermospray liquid chromatography/mass spectrometry, Biomedical and Environmental Mass Spectrometry, 18, pp. 935-938, (1989)
[7] Dalrymple R.H., Ingle D.L., Effects of the beta-agonist CIM on the growth, food efficiency and carcass composition in poultry in the USA, Beta-Agonists and Their Effects on Animal Growth and Carcass Quality, pp. 163-172, (1987)
[8] Degroot J.M., Bukanski B., Beerman H., Courtheyn D., Clenbuterol residue analysis by HPLC-HPTLC in urine and animal tissues, Zeitschrift für Lebensmittel Untersuchung Und Forschung, 189, pp. 128-131, (1989)
[9] Delahaut P., Dubois M., Pribar O., Buchanan G., Degands G., Ectors F., Development of a specific radioimmunoassay for the detection of clenbuterol residues in treated cattle, Food Additives and Contaminants, 8, pp. 43-53, (1991)
[10] Fleeker J.R., Lovett L.J., Enzyme immunoassay for screening sulphamethazine residues in swine blood, Journal of the Association of Official Analytical Chemists, 88, pp. 172-174, (1985)

← 1 2 →