(+)- AND ENT-(-)-DUOCARMYCIN SA AND (+)- AND ENT-(-)-N-BOC-DSA DNA ALKYLATION PROPERTIES - ALKYLATION SITE MODELS THAT ACCOMMODATE THE OFFSET AT-RICH ADENINE N3 ALKYLATION SELECTIVITY OF THE ENANTIOMERIC AGENTS

被引：135

作者：

BOGER, DL

JOHNSON, DS

YUN, WY

机构：

[1] Department of Chemistry, Scripps Research Institute, California, 10666 North Torrey Pines Road, La Jolla

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1994年 / 116卷 / 05期

关键词：

D O I：

10.1021/ja00084a004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A detailed study of the DNA alkylation properties of (+)-duocarmycin SA, ent-(-)-duocarmycin SA, and (+)- and ent-(-)-N-BOC-DSA (2) is described, and the development of a model that accommodates the offset AT-rich adenine N3 alkylation selectivity of the enantiomeric agents is presented.

引用

页码：1635 / 1656

页数：22

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