THE ABSENCE OF ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES IN PATIENTS WITH HENOCH-SCHONLEIN PURPURA

被引:23
作者
ROBSON, WLM
LEUNG, AKC
WOODMAN, RC
机构
[1] Department of Pediatric Nephrology, The Children's Hospital, Greenville, 29605, South Carolina
[2] Department of Pediatrics, University of Calgary, Alberta Children's Hospital, Calgary, Alberta
[3] Department of Internal Medicine, The Foothills Provincial Hospital, Calgary, Alberta
关键词
HENOCH-SCHBOLEIN PURPURA; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; GLOMERULONEPHRITIS; VASCULITIS;
D O I
10.1007/BF00866339
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Sera from 14 patients with acute Henoch-Schonlein purpura (HSP) and 5 patients with a past history of HSP were assessed using a immunofluorescence technique for the presence of IgG, IgA, and IgM anti-neutrophil cytoplasmic antibodies (ANCA). There was no evidence of IgG, IgA, or IgM ANCA in the sera of these patients. These results suggest that ANCA are not involved in the pathogenesis of HSP.
引用
收藏
页码:295 / 298
页数:4
相关论文
共 35 条
[1]  
Davies D.J., Moran J.E., Niall J.F., Ryan G.B., Segmental necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology?, BMJ, 285, (1982)
[2]  
van der Woude F.J., Rasmussen N., Lobatto S., Wiik A., Permin H., van Es L.A., van der Giessen M., van der Hem G.K., The T.H., Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker for disease activity in Wegener's granulomatosis, Lancet, 1, pp. 425-429, (1985)
[3]  
Savage C.O.S., Winearls C.G., Jones S., Marshall P.D., Lockwood C.M., Prospective study of radioimmunoassay for antibodies against neutrophil cytoplasm in the diagnosis of systemic vasculitis, Lancet, 1, pp. 1389-1393, (1987)
[4]  
Dillon M.J., Tizard E.J., Anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies, Pediatr Nephrol, 5, pp. 256-259, (1991)
[5]  
Falk R.J., ANCA-associated renal disease, Kidney Int, 38, pp. 988-1010, (1990)
[6]  
Cameron J.S., Renal disease and vasculitis, Pediatr Nephrol, 2, pp. 490-497, (1988)
[7]  
Baldree L.A., Gaber L.W., McKay C.P., Anti-neutrophil cytoplasmic autoantibodies in a child with pauci-immune necrotizing and crescentic glomerulonephritis, Pediatr Nephrol, 5, pp. 296-299, (1991)
[8]  
Lockwood C.M., Specificity and pathogenicity of antineutrophil cytoplasm antibodies, Exp Nephrol, 1, pp. 13-18, (1993)
[9]  
Savage C.O.S., Tizard J., Jayne D.R.W., Lockwood C.M., Dillon M.J., Antineutrophil cytoplasmic antibodies in Kawasaki disease, Arch Dis Child, 64, pp. 360-363, (1989)
[10]  
Falk R.J., Jennette C.J., Antineutrophil cytoplasmic auto-antibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis, N Engl J Med, 318, pp. 1651-1657, (1988)