LONG-TERM TREATMENT OF CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY TRANSFORMING GROWTH-FACTOR-BETA-2

被引:76
作者
RACKE, MK
SRIRAM, S
CARLINO, J
CANNELLA, B
RAINE, CS
MCFARLIN, DE
机构
[1] UNIV VERMONT, DEPT NEUROL, BURLINGTON, VT 05405 USA
[2] CELTRIX PHARMACEUT, SANTA CLARA, CA USA
[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT PATHOL NEUROPATHOL, BRONX, NY 10461 USA
关键词
AUTOIMMUNITY; DEMYELINATION; CYTOKINE; INFLAMMATION; IMMUNOPATHOLOGY;
D O I
10.1016/0165-5728(93)90247-V
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It had been demonstrated previously that the administration of transforming growth factor-beta1 (TGF-beta1) reduced the clinical severity of experimental allergic encephalomyelitis (EAE). Treatment with the related immunosuppressive molecule, TGF-beta2, resulted in similar inhibition of T cell activation and proliferation in vitro. Long-term treatment was effective in reducing clinical severity of EAE and the number of relapses in mice receiving either myelin basic protein- or peptide-91-103-specific T cell lines. When examined histologically, mice that had received TGF-beta2 demonstrated significantly less inflammation and demyelination in the central nervous system. Examination of other organs demonstrated no pathology or deleterious side effects from long-term TGF-beta2 therapy. These findings have relevance for the use of TGF-beta2 as a therapeutic agent for the human demyelinating disease, multiple sclerosis.
引用
收藏
页码:175 / 184
页数:10
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