CLINICAL SAFETY OF LIDOCAINE IN PATIENTS WITH COCAINE-ASSOCIATED MYOCARDIAL-INFARCTION

被引：39

作者：

SHIH, RD ^{[1
]}

HOLLANDER, JE ^{[1
]}

BURSTEIN, JL ^{[1
]}

NELSON, LS ^{[1
]}

HOFFMAN, RS ^{[1
]}

QUICK, AM ^{[1
]}

机构：

[1] NYU,BELLEVUE HOSP CTR,DEPT EMERGENCY MED,NEW YORK,NY 10016

来源：

ANNALS OF EMERGENCY MEDICINE | 1995年 / 26卷 / 06期

关键词：

D O I：

10.1016/S0196-0644(95)70041-2

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Study objective: To evaluate the safety of lidocaine in the setting of cocaine-induced myocardial infarction (MI). Design: A retrospective, multicenter study. Setting: Twenty-nine university, university-affiliated, or community hospitals during a 6-year period (total of 117 cumulative hospital-years). Participants: Patients with cocaine-associated MI who received lidocaine in the emergency department. Results: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited brady-dyshythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%). Conclusion: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.

引用

页码：702 / 706

页数：5

共 31 条

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