CYTOSTATIC MECHANISM OF ACTION OF N-METHYL-N-BETA-CHLOROETHYL-HYDRAZINE AND ITS BENZALDEHYDHYDRAZONE

被引：4

作者：

BRAUN, R ^{[1
]}

MANGOLD, U ^{[1
]}

MANGOLD, R ^{[1
]}

机构：

[1] UNIV MARBURG, INST PHARMAKOL & TOXIKOL, D-3550 MARBURG, BUNDES REPUBLIK

来源：

ZEITSCHRIFT FUR KREBSFORSCHUNG UND KLINISCHE ONKOLOGIE | 1976年 / 87卷 / 03期

关键词：

D O I：

10.1007/BF00506502

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

N-Methyl-N-.beta.-chloroethyl-hydrazine and its benzaldehyde hydrazone inhibit the synthesis of DNA and RNA in [mouse] ascites cells in vitro faster and stronger than N,N-dimethylhydrazine and procarbazina. The benzaldehydehydrazone essentially inhibits influx and phosphorylation of nucleosides, whereas N-Methyl-N-.beta.-chloroethylhydrazine acts directly on DNA synthesis.

引用

页码：291 / 299

页数：9

共 8 条

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[2]

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