PHARMACOLOGICAL PROPERTIES OF THE NMDA RECEPTOR INVOLVED IN SOMATOSTATIN RELEASE FROM CORTICAL-NEURONS

被引：7

作者：

TAPIAARANCIBIA, L

ASTIER, H

机构：

[1] Unité de Neurobiologie Endocrinologique, UA 1197, CNRS, Université de Montpellier II, Place E. Bataillon

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 186卷 / 2-3期

关键词：

Cortical neurons; D-Serine; Kynurenic acid; NMDA receptors; Somatostatin; Zn[!sup]2+[!/sup;

D O I：

10.1016/0014-2999(90)90452-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glutamate increases somatostatin release from cultured cerebral cortical neurons, presumably through a N-methyl-D-aspartate (NMDA) receptor type. We report here that the NMDA response was potentiated by D-serine (10 μM) and that this potentiation was blocked by kynurenic acid (4-hydroxyquinoline-2-carboxylic acid; KYN). A higher concentration of D-serine (100 μM) reduced the antagonistic effect of KYN. Furthermore, the NMDA response exhibited another characteristic property of the NMDA receptor: it was decreased by low concentration of Zn2+ (50 μM). In contrast, Zn2+ slightly but significantly potentiated the quisqualate (QA)- and kainate (KA)-induced responses. © 1990.

引用

页码：319 / 322

页数：4

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