ATROPINE INHIBITION OF THE CARDIO-DEPRESSIVE EFFECT OF MONO(2-ETHYLHEXYL)PHTHALATE ON HUMAN MYOCARDIUM

被引：23

作者：

BARRY, YA ^{[1
]}

LABOW, RS ^{[1
]}

KEON, WJ ^{[1
]}

TOCCHI, M ^{[1
]}

机构：

[1] CANADIAN RED CROSS,BLOOD TRANSFUS SERV,OTTAWA CTR,OTTAWA K1S 3E2,ONTARIO,CANADA

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1990年 / 106卷 / 01期

关键词：

D O I：

10.1016/0041-008X(90)90104-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Di(2-ethylhexyl)phthalate (DEHP) is a commonly used plasticizer in polyvinylchloride (PVC)-derived plastic. Mono(2-ethylhexyl)phthalate (MEHP), the major metabolite of DEHP, had a reversible, concentration-dependent (15-200 μg/ml) negative inotropic effect on a human in vitro atrial trabecular isometric preparation with an IC50 of 85 μg/ml. When atropine (22-32 μg/ml) was included in the atrial preparation the IC50 was shifted to > 120 μg/ml, suggesting that MEHP acts in part through the cholinergic receptors. © 1990.

引用

页码：48 / 52

页数：5

共 20 条

[1]

BARRY YA, 1988, BLOOD, V72, P1438

[2]

BARRY YA, 1989, J THORAC CARDIOV SUR, V97, P900

[3]

CHU I, 1978, DRUG METAB DISPOS, V6, P146

[4] CONTAMINATION OF COMMERCIAL BLOOD PRODUCTS BY DI-2-ETHYLHEXYL PHTHALATE AND MONO-2-ETHYLHEXYL PHTHALATE [J].

COLE, RS ;

TOCCHI, M ;

WYE, E ;

VILLENEUVE, DC ;

ROCK, G .

VOX SANGUINIS, 1981, 40 (05) :317-322

[5]

DEBOLD AJ, 1986, J HYPERTENS S2, V4, P53

[6] AMINO ACID METABOLISM IN MAMMALIAN CELL CULTURES [J].

EAGLE, H .

SCIENCE, 1959, 130 (3373) :432-437

[7] TESTICULAR EFFECTS OF PHTHALATE-ESTERS [J].

GANGOLLI, SD .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1982, 45 (NOV) :77-84

[8] SPECIES-DIFFERENCES IN THE TESTICULAR TOXICITY OF PHTHALATE-ESTERS [J].

GRAY, TJB ;

ROWLAND, IR ;

FOSTER, PMD ;

GANGOLLI, SD .

TOXICOLOGY LETTERS, 1982, 11 (1-2) :141-147

[9]

KEON WJ, 1984, CAN J SURG, V27, P372

[10] CARDIAC TRANSPLANTATION - THE IDEAL MYOCARDIAL TEMPERATURE FOR GRAFT TRANSPORT [J].

KEON, WJ ;

HENDRY, PJ ;

TAICHMAN, GC ;

MAINWOOD, GW .

ANNALS OF THORACIC SURGERY, 1988, 46 (03) :337-341

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