SALIVA OF THE TICK IXODES-DAMMINI INHIBITS NEUTROPHIL FUNCTION

被引：140

作者：

RIBEIRO, JMC

WEIS, JJ

TELFORD, SR

机构：

[1] HARVARD UNIV, SCH PUBL HLTH, DEPT TROP PUBL HLTH, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT RHEUMATOL & IMMUNOL, BOSTON, MA 02115 USA

来源：

EXPERIMENTAL PARASITOLOGY | 1990年 / 70卷 / 04期

关键词：

Acari; anaphylatoxin; Arthropod salivary gland; Borrelia burgdorferi; Ectoparasite; Ixodes dammini; Ixodidae; Neutrophil aggregation; Neutrophil glucuronidase secretion; Neutrophil phagocytosis; Neutrophil superoxide secretion;

D O I：

10.1016/0014-4894(90)90121-R

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Pilocarpine-induced saliva of adult female Ixodes dammini ticks inhibits the function of peritonealderived rat neutrophils, as measured by anaphylatoxin-induced aggregation, FMLP-induced granule enzyme secretion, zymosan-induced superoxide secretion, and phagocytosis of Borrelia burgdorferi spirochetes. Inhibition ranged from 40 to 80% when saliva was diluted 20 times into the assay medium. This neutrophil-inhibiting activity of I. dammini saliva may aid in tick feeding and facilitate pathogen transmission. © 1990.

引用

页码：382 / 388

页数：7

共 35 条

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