HEPATITIS-C ANTIBODY PROFILE AND VIREMIA PREVALENCE IN ADULTS WITH SEVERE HEMOPHILIA

被引:44
作者
TEDDER, RS
BRIGGS, M
RING, C
TUKE, PW
JONES, P
SAVIDGE, GF
RODGERS, B
GARSON, JA
机构
[1] UNIV COLL & MIDDLESEX SCH MED,SCH PATHOL,DEPT MED MICROBIOL,67 RIDINGHOUSE ST,LONDON W1P 7PN,ENGLAND
[2] ROYAL VICTORIA INFIRM,NO REG HAEMOPHILIA SERV,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND
[3] ST THOMAS HOSP,CTR HAEMOPHILIA,LONDON SE1 7EH,ENGLAND
[4] WELLCOME FDN LTD,BECKENHAM,KENT,ENGLAND
关键词
D O I
10.1111/j.1365-2141.1991.tb08064.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sera from 21 patients who had received large amounts of unheated factor VIII concentrate were tested for antibodies to the hepatitis C virus (HCV) by both commercial (Ortho C100 and 'in house' ELISAs. 'In house' assays utilized recombinant structural (core) or non-structural (replicase) HCV proteins generated by a baculovirus expression system. Antibodies to HCV were detected in 100% of the sera by the core protein based ELISA but in only 62% and 19% by the C100 and replicase based ELISAs, respectively. Hepatitis C viraemia was demonstrated in 90% of the patients by in vitro amplification of the 5' non-coding region of the HCV genome. Amplification with primer sets from two other regions of the genome proved less efficient at detecting viraemia. We conclude that the prevalence of hepatitis C infection in haemophiliacs may have been underestimated previously and that almost all HCV-infected patients have evidence of on-going viral replication.
引用
收藏
页码:512 / 515
页数:4
相关论文
共 20 条
[1]   EFFECT OF ALPHA-INTERFERON THERAPY ON HEPATITIS-C VIREMIA IN COMMUNITY-ACQUIRED CHRONIC NON-A-HEPATITIS, NON-B-HEPATITIS - A QUANTITATIVE POLYMERASE CHAIN-REACTION STUDY [J].
BRILLANTI, S ;
GARSON, JA ;
TUKE, PW ;
RING, C ;
BRIGGS, M ;
MASCI, C ;
MIGLIOLI, M ;
BARBARA, L ;
TEDDER, RS .
JOURNAL OF MEDICAL VIROLOGY, 1991, 34 (02) :136-141
[2]  
CEDERBAUM AI, 1982, ARCH INTERN MED, V142, P481, DOI 10.1001/archinte.142.3.481
[3]   ISOLATION OF A CDNA CLONE DERIVED FROM A BLOOD-BORNE NON-A, NON-B VIRAL-HEPATITIS GENOME [J].
CHOO, QL ;
KUO, G ;
WEINER, AJ ;
OVERBY, LR ;
BRADLEY, DW ;
HOUGHTON, M .
SCIENCE, 1989, 244 (4902) :359-362
[4]   2ND GENERATION TESTS IN DIAGNOSIS OF CHRONIC HEPATITIS-C [J].
CRAXI, A ;
FIORENTINO, G ;
DIMARCO, V ;
MARINO, L ;
MAGRIN, S ;
FABRIANO, C ;
PAGLIARO, L .
LANCET, 1991, 337 (8753) :1354-1354
[5]  
ESTEBAN JI, 1990, LANCET, V336, P294
[6]  
EYSTER ME, 1985, BLOOD, V66, P1317
[7]   NON-A NON-B HEPATITIS AFTER TRANSFUSION OF FACTOR-VIII IN INFREQUENTLY TREATED PATIENTS [J].
FLETCHER, ML ;
TROWELL, JM ;
CRASKE, J ;
PAVIER, K ;
RIZZA, CR .
BRITISH MEDICAL JOURNAL, 1983, 287 (6407) :1754-1757
[8]   DETECTION BY PCR OF HEPATITIS-C VIRUS IN FACTOR-VIII CONCENTRATES [J].
GARSON, JA ;
PRESTON, FE ;
MAKRIS, M ;
TUKE, P ;
RING, C ;
MACHIN, SJ ;
TEDDER, RS .
LANCET, 1990, 335 (8703) :1473-1473
[9]   DETECTION OF HEPATITIS-C VIRAL SEQUENCES IN BLOOD DONATIONS BY NESTED POLYMERASE CHAIN-REACTION AND PREDICTION OF INFECTIVITY [J].
GARSON, JA ;
TEDDER, RS ;
BRIGGS, M ;
TUKE, P ;
GLAZEBROOK, JA ;
TRUTE, A ;
PARKER, D ;
BARBARA, JAJ ;
CONTRERAS, M ;
ALOYSIUS, S .
LANCET, 1990, 335 (8703) :1419-1422
[10]   DEMONSTRATION OF VIREMIA PATTERNS IN HEMOPHILIACS TREATED WITH HEPATITIS-C-VIRUS-CONTAMINATED FACTOR-VIII CONCENTRATES [J].
GARSON, JA ;
TUKE, PW ;
MAKRIS, M ;
BRIGGS, M ;
MACHIN, SJ ;
PRESTON, FE ;
TEDDER, RS .
LANCET, 1990, 336 (8722) :1022-1025