RETRACTED: miR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation (Retracted article. See vol. 40, pg. 1440, 2022)

被引：644

作者：

Garofalo, Michela ^{[2
]}

Di Leva, Gianpiero ^{[2
]}

Romano, Giulia ^{[3
]}

Nuovo, Gerard ^{[2
]}

Suh, Sung-Suk ^{[2
]}

Ngankeu, Apollinaire ^{[2
]}

Taccioli, Cristian ^{[2
]}

Pichiorri, Flavia ^{[2
]}

Alder, Hansjuerg ^{[2
]}

Secchiero, Paola ^{[4
]}

Gasparini, Pierluigi ^{[2
]}

Gonelli, Arianna ^{[4
]}

Costinean, Stefan ^{[2
]}

Acunzo, Mario ^{[2
]}

Condorelli, Gerolama ^{[1
]}

Croce, Carlo Maria ^{[2
]}

机构：

[1] Univ Naples Federico II, Dept Cellular & Mol Biol & Pathol, Ist Endocrinol & Oncol Sperimentale G Salvatore, CNR,Fac Biotechnol Sci, I-80121 Naples, Italy

[2] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[3] Fdn SDN, I-80143 Naples, Italy

[4] Univ Ferrara, Human Anat Sect, Dept Morphol & Embryol, I-44100 Ferrara, Italy

来源：

CANCER CELL | 2009年 / 16卷 / 06期

关键词：

CELL LUNG-CANCER; TISSUE INHIBITOR; IN-VITRO; MATRIX METALLOPROTEINASES; MICRORNA SIGNATURES; JUN-B; C-MET; APOPTOSIS; EXPRESSION; INVASION;

D O I：

10.1016/j.ccr.2009.10.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung and liver cancers are among the most deadly types of cancer. Despite improvements in treatment over the past few decades, patient survival remains poor, underlining the need for development of targeted therapies. MicroRNAs represent a class of small RNAs frequently deregulated in human malignancies. We now report that miR-221&222 are overexpressed in aggressive non-small cell lung cancer and hepatocarcinoma cells, as compared with less invasive and/or normal lung and liver cells. We show that miR-221&222, by targeting PTEN and TIMP3 tumor suppressors, induce TRAIL resistance and enhance cellular migration through the activation of the AKT pathway and metallopeptidases. Finally, we demonstrate that the MET oncogene is involved in miR-221&222 activation through the c-Jun transcription factor.

引用

页码：498 / 509

页数：12

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