Calcium-permeable AMPA receptors in neonatal hypoxic-ischemic encephalopathy (Review)

被引：28

作者：

Tang, Xiao-Juan ^{[1
]}

Xing, Feng ^{[1
]}

机构：

[1] Soochow Univ, Childrens Hosp, Dept Neonatol, 303 Jingde Rd, Suzhou 215003, Jiangsu, Peoples R China

来源：

BIOMEDICAL REPORTS | 2013年 / 1卷 / 06期

基金：

中国国家自然科学基金;

关键词：

hypoxic-ischemic encephalopathy; neonate; Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; glutamate receptors 2;

D O I：

10.3892/br.2013.154

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and may result in long-term devastating consequences. Excessive stimulation of glutamate receptors (GluRs) is a pivotal mechanism underlying ischemia-induced selective and delayed neuronal death. Although initial studies focused on N-methyl-D-aspartic acid (NMDA) receptors as critical mediators in HIE, subsequent studies supported a more central role for aamino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs), particularly Ca2+ -permeable AMPARs, in brain damage associated with hypoxia-ischemia. This study reviewedthe important role of Ca2+ -permeable AMPARs in HIE and the future potential neuroprotective strategies associated with Ca2+ -permeable AMPARs.

引用

收藏

页码：828 / 832

页数：5

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