IMMUNOLOGICAL CROSS-REACTIVITY BETWEEN THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIRION INFECTIVITY FACTOR AND A 170-KD SURFACE-ANTIGEN OF SCHISTOSOMA-MANSONI

被引：29

作者：

KHALIFE, J

GRZYCH, JM

PIERCE, R

AMEISEN, JC

SCHACHT, AM

GRASMASSE, H

TARTAR, A

LECOCQ, JP

CAPRON, A

机构：

[1] TRANSGENE SA,F-68000 STRASBOURG,FRANCE

[2] INST PASTEUR,UNITE CHIM BIOMOLEC,F-59019 LILLE,FRANCE

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 172卷 / 03期

关键词：

D O I：

10.1084/jem.172.3.1001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A monoclonal antibody (mAb) directed against a synthetic peptide derived from the sequence of the human immunodeficiency virus type 1(HIV1) regulatory protein virion infectivity factor (vif) labeled the surface of Schistosoma mansoni schistosomula by indirect immunofluorescence. Western blotting showed that two S. mansoni proteins of 170 and 65 kD were recognized by the mAb. Sera from 20% of S. mansoni-infected HIVseronegative individuals tested recognized the PS4 peptide in an ELISA as did sera from S. mansoni-infected rats. Sera from individuals seropositive for HIV-1, but without schistosomiasis, that reacted with the vifpeptide also recognized a 170-kD S. mansoni protein. This crossreactive S. mansoni antigen appears to be a target of immunity in vivo since passive transfer of the mAb VIF-CD3 to naive rats had a protective effect against a challenge infection with S. mansoni cercariae. © 1990, Rockefeller University Press., All rights reserved.

引用

页码：1001 / 1004

页数：4

共 16 条

[1] ANTIBODIES TO THE NEF PROTEIN AND TO NEF PEPTIDES IN HIV-1-INFECTED SERONEGATIVE INDIVIDUALS [J].

AMEISEN, JC ;

GUY, B ;

CHAMARET, S ;

LOCHE, M ;

MOUTON, Y ;

NEYRINCK, JL ;

KHALIFE, J ;

LEPREVOST, C ;

BEAUCAIRE, G ;

BOUTILLON, C ;

GRASMASSE, H ;

MANIEZ, M ;

KIENY, MP ;

LAUSTRIAT, D ;

BERTHIER, A ;

MACH, B ;

MONTAGNIER, L ;

LECOCQ, JP ;

CAPRON, A .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1989, 5 (03) :279-291

[2] REGIONAL VARIATION IN PREVALENCE OF ANTIBODY AGAINST HUMAN LYMPHOTROPIC-T VIRUS TYPE-1 AND TYPE-3 IN KENYA, EAST-AFRICA [J].

BIGGAR, RJ ;

JOHNSON, BK ;

OSTER, C ;

SARIN, PS ;

OCHENG, D ;

TUKEI, P ;

NSANZE, H ;

ALEXANDER, S ;

BODNER, AJ ;

SIONGOK, TA ;

GALLO, RC ;

BLATTNER, WA .

INTERNATIONAL JOURNAL OF CANCER, 1985, 35 (06) :763-767

[3]

BIGGAR RJ, 1985, LANCET, V2, P520

[4] IMMUNITY AFTER TREATMENT OF HUMAN SCHISTOSOMIASIS MANSONI .2. IDENTIFICATION OF RESISTANT INDIVIDUALS, AND ANALYSIS OF THEIR IMMUNE-RESPONSES [J].

BUTTERWORTH, AE ;

CAPRON, M ;

CORDINGLEY, JS ;

DALTON, PR ;

DUNNE, DW ;

KARIUKI, HC ;

KIMANI, G ;

KOECH, D ;

MUGAMBI, M ;

OUMA, JH ;

PRENTICE, MA ;

RICHARDSON, BA ;

SIONGOK, TKA ;

STURROCK, RF ;

TAYLOR, DW .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1985, 79 (03) :393-408

[5] IMMUNITY AFTER TREATMENT OF HUMAN SCHISTOSOMIASIS MANSONI .1. STUDY DESIGN, PRETREATMENT OBSERVATIONS AND THE RESULTS OF TREATMENT [J].

BUTTERWORTH, AE ;

DALTON, PR ;

DUNNE, DW ;

MUGAMBI, M ;

OUMA, JH ;

RICHARDSON, BA ;

SIONGOK, TKA ;

STURROCK, RF .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1984, 78 (01) :108-123

[6]

Clegg J A, 1972, Int J Parasitol, V2, P79, DOI 10.1016/0020-7519(72)90036-7

[7]

DELIMA ECM, 1988, T R SOC TROP MED HYG, V82, P262

[8]

GRZYCH JM, 1982, J IMMUNOL, V129, P2739

[9] HIV F/3' ORF ENCODES A PHOSPHORYLATED GTP-BINDING PROTEIN RESEMBLING AN ONCOGENE PRODUCT [J].

GUY, B ;

KIENY, MP ;

RIVIERE, Y ;

LEPEUCH, C ;

DOTT, K ;

GIRARD, M ;

MONTAGNIER, L ;

LECOCQ, JP .

NATURE, 1987, 330 (6145) :266-269

[10] IMMUNITY IN HUMAN SCHISTOSOMIASIS-MANSONI - REGULATION OF PROTECTIVE IMMUNE-MECHANISMS BY IGM BLOCKING ANTIBODIES [J].

KHALIFE, J ;

CAPRON, M ;

CAPRON, A ;

GRZYCH, JM ;

BUTTERWORTH, AE ;

DUNNE, DW ;

OUMA, JH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (05) :1626-1640

← 1 2 →