C-ERBB-2 PROTOONCOGENE EXPRESSION AND ITS RELATIONSHIP TO SURVIVAL IN GASTRIC-CARCINOMA - AN IMMUNOHISTOCHEMICAL STUDY ON ARCHIVAL MATERIAL

被引：80

作者：

JAIN, S

FILIPE, MI

GULLICK, WJ

LINEHAN, J

MORRIS, RW

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT PUBL HLTH,LONDON SE1 9RT,ENGLAND

[2] HAMMERSMITH HOSP,IMPERIAL CANC RES FUND,ONCOL GRP,LONDON W12 0HS,ENGLAND

来源：

INTERNATIONAL JOURNAL OF CANCER | 1991年 / 48卷 / 05期

关键词：

D O I：

10.1002/ijc.2910480506

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The c-erbB-2 proto-oncogene encodes a growth factor receptor which is over-expressed in a variety of human adenocarcinomas. Recent reports suggest that it may be of value in arriving at prognosis in breast and ovarian cancer. In this study, c-erbB-2 expression was investigated in 93 routinely processed cases of gastric carcinoma, using an immunohistochemical technique. c-erbB-2 membrane immunoreactivity was observed in 11% (10/93) of tumours, all of which were of the well differentiated intestinal type (p < 0.01). Overall, patients with tumours expressing this proto-oncogene had a significantly improved prognosis (p < 0.05). Within the group of intestinal-type tumours, those that were c-erbB-2-positive formed a distinct sub-population which had a better prognosis (p < 0.02), suggesting possible differences in aetiology.

引用

页码：668 / 671

页数：4

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