EFFECT OF INTERLEUKIN-3 ON RESPONSIVENESS TO GRANULOCYTE-COLONY-STIMULATING FACTOR IN SEVERE APLASTIC-ANEMIA

被引：25

作者：

GEISSLER, K

FORSTINGER, C

KALHS, P

KNOBL, P

KIER, P

KYRLE, P

LECHNER, K

机构：

[1] University of Vienna, Vienna

[2] First Clinic of Internal Medicine, University of Vienna, A-1090 Vienna

来源：

ANNALS OF INTERNAL MEDICINE | 1992年 / 117卷 / 03期

关键词：

ANEMIA; GRANULOCYTE COLONY-STIMULATING FACTOR; INTERLEUKIN-3; HEMATOPOIETIC CELL GROWTH FACTORS; HEMATOPOIESIS;

D O I：

10.7326/0003-4819-117-3-223

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with severe aplastic anemia rarcly respond to monotherapy with hematopoietic growth factors. This inadequate response is thought to be caused by a deficiency in hematopoietic progenitors. Interleukin-3 has recently been reported to expand the pool of hematopoictic progenitors in primates. This report describes a patient with severe, refractory aplastic anemia who initially failed to respond to treatment with granulocyte-colony-stimulating factor but who showed a dramatic response to the same agent after pretreatment with interleukin-3.

引用

页码：223 / 225

页数：3

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