INCIDENCE OF ZIDOVUDINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS ISOLATED FROM PATIENTS BEFORE, DURING, AND AFTER THERAPY

被引：52

作者：

LAND, S ^{[1
]}

MCGAVIN, C ^{[1
]}

LUCAS, R ^{[1
]}

BIRCH, C ^{[1
]}

机构：

[1] FAIRFIELD HOSP,DIV MED,FAIRFIELD,VIC,AUSTRALIA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1992年 / 166卷 / 05期

关键词：

D O I：

10.1093/infdis/166.5.1139

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The zidovudine sensitivity of 372 isolates of human immunodeficiency virus (HIV) obtained from 237 patients before, during, and after treatment with zidovudine was examined. Virus resistant to >0.5 mug/mL (1.87 muM) zidovudine was isolated from most patients (93%) after 36 months of therapy. Zidovudine-sensitive virus was isolated from 5 of 15 patients who had ended antiretroviral therapy but had previously shed resistant virus. The emergence of sensitive virus after end of therapy appeared to be influenced by both the duration of treatment and the time off drug. Patients with resistant virus tended to have low CD4 cell counts and HIV antigenemia at the commencement of therapy, suggesting that these two factors are important in the development of drug resistance.

引用

收藏

页码：1139 / 1142

页数：4

相关论文

共 15 条

[1] ZIDOVUDINE SENSITIVITY OF HUMAN IMMUNODEFICIENCY VIRUSES FROM HIGH-RISK, SYMPTOM-FREE INDIVIDUALS DURING THERAPY [J].

BOUCHER, CAB ;

TERSMETTE, M ;

LANGE, JMA ;

KELLAM, P ;

DEGOEDE, REY ;

MULDER, JW ;

DARBY, G ;

GOUDSMIT, J ;

LARDER, BA .

LANCET, 1990, 336 (8715) :585-590

[2] A PILOT-STUDY OF LOW-DOSE ZIDOVUDINE IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J].

COLLIER, AC ;

BOZZETTE, S ;

COOMBS, RW ;

CAUSEY, DM ;

SCHOENFELD, DA ;

SPECTOR, SA ;

PETTINELLI, CB ;

DAVIES, G ;

RICHMAN, DD ;

LEEDOM, JM ;

KIDD, P ;

COREY, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (15) :1015-1021

[3] PLASMA VIREMIA IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTION [J].

COOMBS, RW ;

COLLIER, AC ;

ALLAIN, JP ;

NIKORA, B ;

LEUTHER, M ;

GJERSET, GF ;

COREY, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (24) :1626-1631

[4] A RANDOMIZED CONTROLLED TRIAL OF A REDUCED DAILY DOSE OF ZIDOVUDINE IN PATIENTS WITH THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].

FISCHL, MA ;

PARKER, CB ;

PETTINELLI, C ;

WULFSOHN, M ;

HIRSCH, MS ;

COLLIER, AC ;

ANTONISKIS, D ;

HO, M ;

RICHMAN, DD ;

FUCHS, E ;

MERIGAN, TC ;

REICHMAN, RC ;

GOLD, J ;

STEIGBIGEL, N ;

LEOUNG, GS ;

RASHEED, S ;

TSIATIS, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (15) :1009-1014

[5]

GREGERSON JP, 1988, J VIROL METHODS, V189, P161

[6] AZIDOTHYMIDINE [J].

HIRSCH, MS .

JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (03) :427-431

[7] QUANTITATION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 IN THE BLOOD OF INFECTED PERSONS [J].

HO, DD ;

MOUDGIL, T ;

ALAM, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (24) :1621-1625

[8] DECREASED INVITRO SUSCEPTIBILITY TO ZIDOVUDINE OF HIV ISOLATES OBTAINED FROM PATIENTS WITH AIDS [J].

LAND, S ;

TRELOAR, G ;

MCPHEE, D ;

BIRCH, C ;

DOHERTY, R ;

COOPER, D ;

GUST, I .

JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (02) :326-329

[9] HIV WITH REDUCED SENSITIVITY TO ZIDOVUDINE (AZT) ISOLATED DURING PROLONGED THERAPY [J].

LARDER, BA ;

DARBY, G ;

RICHMAN, DD .

SCIENCE, 1989, 243 (4899) :1731-1734

[10] MULTIPLE MUTATIONS IN HIV-1 REVERSE-TRANSCRIPTASE CONFER HIGH-LEVEL RESISTANCE TO ZIDOVUDINE (AZT) [J].

LARDER, BA ;

KEMP, SD .

SCIENCE, 1989, 246 (4934) :1155-1158