SYNTHESIS AND CHARACTERIZATION OF ARTIFICIAL RED-CELL (ARC)

被引：13

作者：

TSUCHIDA, E

机构：

[1] Department of Polymer Chemistry, Waseda University, Tokyo

来源：

BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY | 1992年 / 20卷 / 2-4期

关键词：

D O I：

10.3109/10731199209119653

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An unsaturated lipid made from 2,4-octadecadienoic acid was used as a component of phosholipid vesicles. The vesicles (0.2-mu-m-phi) was prepared by an extrusion method, and the unsaturated lipid was polymerized with gamma-ray. Vesicles constructed from the polylipid show enormous stability during long term storage in frozen state and can be handled easily. Negative effect could not be confirmed in vitro tests. This system satisfies all the physiological conditions, such as oxygen transport ability and solution properties as a blood substitute.

引用

页码：337 / 344

页数：8

共 13 条

[1] HEMOGLOBIN-LIPOSOMES AS BLOOD REPLACEMENT FLUID [J].

BRANDL, M ;

BECKER, D ;

BAUER, KH .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1989, 15 (05) :655-669

[2]

DJORDJEVICH L, 1980, EXP HEMATOL, V8, P584

[3]

DJORDJEVICH L, 1988, LIPOSOMES DRUG CARRI, V39

[4]

Farmer M C, 1988, Adv Exp Med Biol, V238, P161

[5]

HASEGAWA E, 1986, BIOCH BIOPHYS ACTA, V862

[6] SYNTHESIS AND EVALUATION OF A PROTOTYPAL ARTIFICIAL RED-CELL [J].

HUNT, CA ;

BURNETTE, RR ;

MACGREGOR, RD ;

STRUBBE, AE ;

LAU, DT ;

TAYLOR, N ;

KIWADA, H .

SCIENCE, 1985, 230 (4730) :1165-1168

[7] PREPARATION OF HEMOGLOBIN-CONTAINING LIPOSOMES USING OCTYL GLUCOSIDE AND OCTYLTETRAOXYETHYLENE [J].

JOPSKI, B ;

PIRKL, V ;

JARONI, HW ;

SCHUBERT, R ;

SCHMIDT, KH .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 978 (01) :79-84

[8]

KIMURA N, 1991, IN PRESS MACROMOLECU, V24

[9]

MILLER IF, 1981, CHEM ENG COMMUN, P363

[10]

RAVINOVICI R, 1989, CIRC SHOCK, V29, P115

← 1 2 →