ANTI-AIDS AGENTS .8. HIV AND REVERSE-TRANSCRIPTASE INHIBITION BY TANNINS

被引：21

作者：

KILKUSKIE, RE

KASHIWADA, Y

NONAKA, G

NISHIOKA, I

BODNER, AJ

CHENG, YC

LEE, KH

机构：

[1] CAMBRIDGE BIOTECH CORP,ROCKVILLE,MD 20850

[2] KYUSHU UNIV,FAC PHARMACEUT SCI,FUKUOKA 812,JAPAN

[3] YALE UNIV,SCH MED,DEPT PHARMACOL,NEW HAVEN,CT 06510

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80422-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Further evaluation of tannins as anti-HIV agents indicates that these compounds inhibited HIV replication only slightly in the absence of toxicity (therapeutic index less-than-or-equal-to 5). In addition, no correlation was found between inhibition of reverse transcriptase and of HIV in cell culture.

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收藏

页码：1529 / 1534

页数：6

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