EXACERBATION OF PNEUMOCYSTIS-CARINII PNEUMONIA IN IMMUNODEFICIENT (SCID) MICE BY CONCURRENT INFECTION WITH A PNEUMOVIRUS

被引：8

作者：

BRAY, MV

BARTHOLD, SW

SIDMAN, CL

ROTHS, J

SMITH, AL

机构：

[1] YALE UNIV, COMPARAT MED SECT, 333 CEDAR ST, POB 3333, NEW HAVEN, CT 06510 USA

[2] UNIV CINCINNATI, MED CTR, DEPT MOLEC GENET BIOCHEM & MICROBIOL, CINCINNATI, OH 45267 USA

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 04期

关键词：

D O I：

10.1128/IAI.61.4.1586-1588.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

scid mice naturally infected with Pneumocystis carinii and inoculated with a normally apathogenic pneumovirus had significantly higher P. carinii cyst counts and developed significantly more severe P. carinii-related disease than did sham-inoculated, P. carinii-infected scid mice. P. carinii-free, virus-infected scid mice survived for 2 months despite high pulmonary virus titers. These results show that a respiratory virus infection can exacerbate P. carinii disease in an immunocompromised-rodent model.

引用

页码：1586 / 1588

页数：3

共 12 条

[1]

[Anonymous], 1980, THEORY PRACTICE HIST

[2]

ARMSTRONG MYK, 1991, J PROTOZOOL, V38, pS136

[3] POLYPEPTIDES OF PNEUMONIA VIRUS OF MICE .1. IMMUNOLOGICAL CROSS-REACTIONS AND POST-TRANSLATIONAL MODIFICATIONS [J].