THE ASSOCIATION OF PREOPERATIVE SERUM TUMOR-MARKERS WITH DUKES STAGE AND SURVIVAL IN COLORECTAL-CANCER

被引：71

作者：

LINDMARK, G

BERGSTROM, R

PAHLMAN, L

GLIMELIUS, B

机构：

[1] UNIV UPPSALA,AKAD SJUKHUSET,DEPT STAT,S-75185 UPPSALA,SWEDEN

[2] UNIV UPPSALA,AKAD SJUKHUSET,DEPT ONCOL,S-75185 UPPSALA,SWEDEN

来源：

BRITISH JOURNAL OF CANCER | 1995年 / 71卷 / 05期

关键词：

TUMOR MARKERS; DUKES STAGE; PROGNOSIS; COLORECTAL CANCER;

D O I：

10.1038/bjc.1995.211

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tumour markers carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA), TPS, CA 19-9, CA 50 and CA 242 were analysed in serum from 203 potentially curable colorectal cancer patients. The levels of all markers increased with increasing tumour stage, and all markers correlated with survival. Multivariate analyses indicated that the Dukes stage had the best prognostic explanatory power, followed by TPA. In the subset of 166 potentially cured patients, the prognostic information by the markers was substantially reduced. We conclude that preoperative serum tumour marker measurements have the potential to aid therapy selection, but also that their clinical usefulness is not immediately apparent.

引用

页码：1090 / 1094

页数：5

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