SEROHEMATOLOGIC ALTERATIONS IN BROILER CHICKS ON FEED AMENDED WITH FUSARIUM-PROLIFERATUM CULTURE MATERIAL OR FUMONISIN B-1 AND MONILIFORMIN

被引：31

作者：

JAVED, T ^{[1
]}

DOMBRINKKURTZMAN, MA ^{[1
]}

RICHARD, JL ^{[1
]}

BENNETT, GA ^{[1
]}

COTE, LM ^{[1
]}

BUCK, WB ^{[1
]}

机构：

[1] USDA ARS,NATL CTR AGR UTILIZAT RES,PEORIA,IL 61604

来源：

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION | 1995年 / 7卷 / 04期

关键词：

D O I：

10.1177/104063879500700417

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Two hundred twenty-eight male broiler chicks (Columbia x New Hampshire) were given feed amended with autoclaved culture material of Fusarium proliferatum containing fumonisin B-1 (FB1) at 61, 193, and 546 ppm, fumonisin B-2 (FB2) at 14, 38, and 98 ppm, and moniliformin at 66, 193, and 367 ppm in 3 separate feeding trials (amounts of toxin in each trial, respectively). Birds were started on amended rations at days 1, 7, and 21 and continued on their respective ration until they were 28 days old. Purified FB1 (125, 274 ppm) and moniliformin (27, 154 ppm) were given separately and in combination (137 and 77 ppm, respectively), starting on day 1 and continuing for 14 days. Of serum chemistry parameters, only glucose was significantly decreased. Significant increases were noted in serum cholesterol, sodium, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and gamma-glutamyl transferase. Of the hematologic parameters, significant decreases were noted in red blood cell counts, hemoglobin, packed cell volume, and white blood cell counts. Immunologic changes included impaired anti-Newcastle disease antibody hemagglutination inhibition titers associated with relative decreases in total serum globulins and increases in albumin/globulin globulin ratios. The changes were noted in all treatment groups when compared to controls.

引用

页码：520 / 526

页数：7

共 27 条

[1]

Bezuidenhout S.C., Gelderblom W.C.A., Gorst-Allman C.P., Et al., Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme, J Chem Soc Commun, pp. 743-745, (1988)

[2]

Coles E.H., Veterinary clinical pathology, (1986)

[3]

Gelderblom W.C.A., Marasas W.F.O., Jaskiewicz K., Et al., Cancer promoting potential of different strains of Fusarium moniliforme, Carcinogenesis, 9, pp. 1405-1409, (1988)

[4]

Harrison L.R., Colvin B.M., Green J.T., Et al., Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme, J Vet Diagn Invest, 2, pp. 217-221, (1990)

[5]

Harrison G.J., Harrison L.R., Clinical avian medicine and surgery, pp. 174-273, (1986)

[6]

Haschek W.M., Motelin G., Ness D.K., Et al., Characterization of fumonisin toxicity in orally and intravenously dosed swine, Mycopathologia, 117, pp. 83-96, (1992)

[7]

Hitchner S.B., Domermuth C.H., Purchase H.G., William J.E., Isolation and identification of avian pathogens., (1980)

[8]

Jaskiewicz K., Marasas W.F.O., Talgaard J.J.F., Hepatitis in vervet monkeys caused by Fusarium moniliforme, J Comp Pathol, 97, pp. 281-291, (1987)

[9]

Javed T., Bennett G.A., Richard J.L., Et al., Mortality in broiler chicks on feed amended with Fusarium proliferatum, Mycopathologia, 123, pp. 171-184, (1993)

[10]

Javed T., Bunte R.M., Bennett G.A., Et al., Comparative pathologic changes in broiler chicks on feed amended with Fusarium proliferatum, J Vet Diagn Invest, (1995)

← 1 2 3 →