SACCHARIN INDUCES CHANGES IN ADENYLATE-CYCLASE ACTIVITY IN LIVER AND MUSCLE MEMBRANES IN RATS

被引：16

作者：

STRIEM, BJ

NAIM, M

ZEHAVI, U

RONEN, T

机构：

[1] HEBREW UNIV JERUSALEM,FAC RADIOIMMUNOL,DEPT BIOCHEM & HUMAN NUTR,IL-76100 REHOVOT,ISRAEL

[2] MONELL CHEM SENSES RES CTR,PHILADELPHIA,PA 19104

来源：

LIFE SCIENCES | 1990年 / 46卷 / 11期

关键词：

D O I：

10.1016/0024-3205(90)90068-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The non-nutritive sweetener, saccharin, was found to stimulate significantly the activity of adenylate cyclase in membranes derived from skeletal muscle of rat. Sodium saccharin enhanced adenylate cyclase activity in a doserelated manner, and this activation appeared to be dependent on the presence of guanine nucleotides, suggesting the involvement of GTP-binding proteins. In membranes derived from the liver, however, sodium saccharin had an effect which was dependent on the concentration of membranes used in the adenylate cyclase assay. In high concentrations of membranes, sodium saccharin had a stimulatory effect, while in low concentration an inhibition was observed. © 1990.

引用

页码：803 / 810

页数：8

共 18 条

[1] RESPONSE OF MALE-RATS TO SODIUM SACCHARIN INGESTION - URINE COMPOSITION AND MINERAL BALANCE [J].