INTESTINAL PSEUDOOBSTRUCTION FOLLOWING THE USE OF ENTERAL CHARCOAL AND SORBITOL AND MECHANICAL VENTILATION WITH PAPAVERETUM SEDATION FOR THEOPHYLLINE POISONING

被引：11

作者：

LONGDON, P ^{[1
]}

HENDERSON, A ^{[1
]}

机构：

[1] PRINCESS ALEXANDRA HOSP,INTENS CARE UNIT,IPSWICH RD,BRISBANE,QLD 4102,AUSTRALIA

来源：

DRUG SAFETY | 1992年 / 7卷 / 01期

关键词：

D O I：

10.2165/00002018-199207010-00009

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We report 2 cases of intestinal pseudo-obstruction, 1 fatal, which developed following the use of enteral activated charcoal with sorbitol, and mechanical ventilation with papaveretum ('Omnopon') sedation for the treatment of severe theophylline self-poisoning. While mechanical intestinal obstruction may rarely complicate the use of enteral activated charcoal, pseudo-obstruction has not been previously described. Causal mechanisms and prophylaxis are discussed, highlighting a possible interaction between theophylline and papaveretum, and the dangers of multidose enteral charcoal with sorbitol in this context.

引用

页码：74 / 77

页数：4

共 14 条

[1]

Burks T.F., Gastrointestinal pharmacology, Annual Review of Pharmacology and Toxicology, 16, pp. 15-31, (1976)

[2]

Garrett J.M., Sauer W.G., Moertel C.G., Colonie motility in ulcerative colitis after opiate administration, Gastroenterology, 53, pp. 93-100, (1967)

[3]

Harsch H.H., Aspiration of activated charcoal, New England Journal of Medicine, 314, (1986)

[4]

Highbee M.D., Kumar M., Galant S.P., Stimulation of endogenous catecholamine release by theophylline: a proposed additional mechanism of theophylline effects, Journal of Allergy and Clinical Immunology, 70, pp. 377-382, (1982)

[5]

Lee J.T., Taylor B.M., Singleton B.C., Epidural anesthesia for pseudo-obstruction of the colon (Ogilvie’s syndrome), Diseases of the Colon and Rectum, 31, pp. 686-691, (1988)

[6]

Mackay A.D., Baldwin C.J., Tattersfield A.E., Action of intravenously administered aminophylline on normal airways, American Review of Respiratory Disease, 127, pp. 609-613, (1983)

[7]

Neuvonen P.J., Olkkola K.T., Oral activated charcoal in the treatment of intoxications: role of single and repeated doses, Medical Toxicology and Adverse Drug Experience, 3, pp. 33-58, (1988)

[8]

Olson K.R., Benowitz N.L., Woo O.F., Pond S.M., Theophylline overdose: acute single ingestion versus chronic repeated overmedication, American Journal of Emergency Medicine, 3, pp. 386-394, (1985)

[9]

Pfaffman M.A., McFarland S.A., Relationship between theophylline induced relaxation and excitation contraction coupling in intestinal smooth muscle, Archives Internationales de Pharmacodynamie et de Thérapie, 232, pp. 180-191, (1978)

[10]

Pond S.M., Role of repeated oral doses of activated charcoal in clinical toxicology, Medical Toxicology, 1, pp. 3-11, (1986)

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