RENAL PROSTAGLANDIN SYNTHESIS AND ANGIOTENSIN-CONVERTING ENZYME-INHIBITION

被引:6
作者
WILSON, TW [1 ]
机构
[1] UNIV SASKATCHEWAN,DEPT MED,SASKATOON S7N 0W0,SASKATCHEWAN,CANADA
关键词
PROSTAGLANDINS; CAPTOPRIL; RENAL CIRCULATION; RENIN-ANGIOTENSIN SYSTEM; NONSTEROIDAL ANTIINFLAMMATORY DRUGS;
D O I
10.1097/00005344-199219006-00008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Renal prostaglandins (PGs) help maintain renal blood flow and glomerular filtration rate when the kidney is exposed to a vasoconstrictor stress. In addition, they aid pressure natriuresis and blunt the antidiuretic effect of vasopressin. Angiotensin-converting enzyme (ACE) inhibitors could decrease renal PG synthesis by reducing angiotensin II (Ang II) formation or increase it by preventing kinin inactivation. Additionally, they could affect PG synthesis or catabolism directly. The effects of ACE inhibitors on blood pressure and renal hemodynamics appear to be largely independent of changes in renal PG synthesis. Similarly, there is no evidence that pressure natriuresis is modified by ACE inhibitors. A kinin induced increase in collecting duct PG synthesis may account for the water diuresis seen clinically with ACE inhibitors. A possible beneficial interaction between thromboxane synthesis inhibitors and ACE inhibitors may exist, Thromboxane synthetase inhibitors can reduce renal vascular resistance by redirecting PG endoperoxide synthesis toward prostacyclin. This effect may be offset by a prostaglandin-induced increase in renin release and Ang II formation. ACE inhibitors, by preventing Ang II synthesis, may increase the vasodilation due to thromboxane synthesis inhibition.
引用
收藏
页码:S39 / S44
页数:6
相关论文
共 51 条
  • [1] ABER GM, 1989, J HYPERTENS S, V7, P815
  • [2] BENHAMIN N, 1989, J PHYSIOL-LONDON, V10, P1143
  • [3] PROSTAGLANDINS IN THE SODIUM EXCRETORY RESPONSE TO ALTERED RENAL ARTERIAL-PRESSURE IN DOGS
    CARMINES, PK
    BELL, PD
    ROMAN, RJ
    WORK, J
    NAVAR, LG
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (01): : F8 - F14
  • [4] EFFECT OF CYCLOOXYGENASE AND THROMBOXANE SYNTHETASE INHIBITION ON FUROSEMIDE-STIMULATED PLASMA-RENIN ACTIVITY
    DATAR, S
    MCCAULEY, FA
    WILSON, TW
    [J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1987, 65 (01) : 80 - 83
  • [5] TESTING THE REDIRECTION HYPOTHESIS OF PROSTAGLANDIN METABOLISM IN THE KIDNEY
    DATAR, S
    MCCAULEY, FA
    WILSON, TW
    [J]. PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1987, 33 (02) : 275 - 285
  • [6] THE EFFECTS OF NAPROXEN AND SULINDAC ON RENAL-FUNCTION AND THEIR INTERACTION WITH HYDROCHLOROTHIAZIDE AND PIRETANIDE IN MAN
    DIXEY, JJ
    NOORMOHAMED, FH
    LANT, AF
    BREWERTON, DA
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 23 (01) : 55 - 63
  • [7] DIETARY-PROTEIN INTAKE MODULATES GLOMERULAR EICOSANOID PRODUCTION IN THE RAT
    DON, BR
    BLAKE, S
    HUTCHISON, FN
    KAYSEN, GA
    SCHAMBELAN, M
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (04): : F711 - F718
  • [8] RENAL EFFECTS OF DRUGS THAT INHIBIT PROSTAGLANDIN SYNTHESIS
    DUNN, MJ
    ZAMBRASKI, EJ
    [J]. KIDNEY INTERNATIONAL, 1980, 18 (05) : 609 - 622
  • [9] PROSTAGLANDINS AND KIDNEY
    DUNN, MJ
    HOOD, VL
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1977, 233 (03): : F169 - F184
  • [10] DUNN MJ, 1983, PROSTAGLANDINS KIDNE, P151