THE INHERITED COMPONENT OF CANCER

被引：48

作者：

EASTON, DF ^{[1
]}

机构：

[1] INST CANC RES, EPIDEMIOL SECT, SURREY, ENGLAND

来源：

BRITISH MEDICAL BULLETIN | 1994年 / 50卷 / 03期

关键词：

D O I：

10.1093/oxfordjournals.bmb.a072908

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

All cancer types exhibit familial clustering, suggestive of a significant inherited component; however, to date only a few of the genes responsible have been identified and the inherited component, if any, underlying most common cancers has not been well defined. Amongst the important known susceptibility genes are those dominant genes conferring a high risk of breast and ovarian cancer (BRCA1), colon cancer (hMSH2 and hMLH1), and melanoma (MLM). Ail these genes confer a high lifetime risk of the disease concerned, but are rare and only account for a small minority (less than 5%) of cases. However, there are also commoner genes conferring lower risks but accounting for a more substantial fraction of cancer cases; those so far identified include the ataxia-telangiectasia gene and the HRAS1 minisatellite locus.

引用

页码：527 / 535

页数：9

共 33 条

[1] GENETIC STEPS IN COLORECTAL-CANCER [J].

BODMER, W ;

BISHOP, T ;

KARRAN, P .

NATURE GENETICS, 1994, 6 (03) :217-219

[2]

BORRESEN AL, 1992, CANCER RES, V52, P3234

[3] MUTATION IN THE DNA MISMATCH REPAIR GENE HOMOLOG HMLH1 IS ASSOCIATED WITH HEREDITARY NONPOLYPOSIS COLON-CANCER [J].

BRONNER, CE ;

BAKER, SM ;

MORRISON, PT ;

WARREN, G ;

SMITH, LG ;

LESCOE, MK ;

KANE, M ;

EARABINO, C ;

LIPFORD, J ;

LINDBLOM, A ;

TANNERGARD, P ;

BOLLAG, RJ ;

GODWIN, AR ;

WARD, DC ;

NORDENSKJOLD, M ;

FISHEL, R ;

KOLODNER, R ;

LISKAY, RM .

NATURE, 1994, 368 (6468) :258-261

[4]

CANNONALBRIGHT LA, 1994, CANCER RES, V54, P2378

[5] ASSIGNMENT OF A LOCUS FOR FAMILIAL MELANOMA, MLM, TO CHROMOSOME-9P13-P22 [J].

CANNONALBRIGHT, LA ;

GOLDGAR, DE ;

MEYER, LJ ;

LEWIS, CM ;

ANDERSON, DE ;

FOUNTAIN, JW ;

HEGI, ME ;

WISEMAN, RW ;

PETTY, EM ;

BALE, AE ;

OLOPADE, OI ;

DIAZ, MO ;

KWIATKOWSKI, DJ ;

PIEPKORN, MW ;

ZONE, JJ ;

SKOLNICK, MH .

SCIENCE, 1992, 258 (5085) :1148-1152

[6] ALLELIC LOSS OF CHROMOSOME-16Q AND CHROMOSOME-10Q IN HUMAN PROSTATE-CANCER [J].

CARTER, BS ;

EWING, CM ;

WARD, WS ;

TREIGER, BF ;

AALDERS, TW ;

SCHALKEN, JA ;

EPSTEIN, JI ;

ISAACS, WB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) :8751-8755

[7] USING AGE OF ONSET TO DISTINGUISH BETWEEN SUBFORMS OF BREAST-CANCER [J].

CLAUS, EB ;

RISCH, NJ ;

THOMPSON, WD .

ANNALS OF HUMAN GENETICS, 1990, 54 :169-177

[8]

CLAUS EB, 1991, AM J HUM GENET, V48, P232

[9]

Doll R, 1981, THE CAUSES OF CANCER

[10]

EASTON D, 1990, CANCER SURV, V9, P395

← 1 2 3 4 →