EFFECT OF LEAD ACETATE AND CARBON PARTICLES ON THE EXPRESSION OF GLUTATHIONE-S-TRANSFERASE YFYF IN RAT-LIVER

被引：7

作者：

BOYCE, SJ

MANTLE, TJ

机构：

[1] Department of Biochemistry, Trinity College

来源：

BIOCHEMICAL JOURNAL | 1993年 / 294卷

关键词：

D O I：

10.1042/bj2940301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Administration of intracardiac lead acetate produces a complex response in glutathione S-transferase (GST) YfYf expression in rat liver. The earliest response, an elevation of GST expression in Kupffer cells, can be mimicked by administering a suspension of carbon particles. The second effect of lead acetate administration is a marked elevation of GST YfYf in some but not all hepatocytes (the 'patchy' response). This effect is most marked 48-76 h after administration of a single dose of lead acetate and is easily detected by immunoblotting. Dexamethasone down-regulates the lead response in hepatocytes.

引用

页码：301 / 304

页数：4

共 31 条

[1]

BECKETT GJ, 1990, GLUTATHIONE S-TRANSFERASES AND DRUG RESISTANCE, P399

[2]

BOYCE SJ, 1987, GLUTATHIONE S TRANSF, P69

[3]

COLUMBANO A, 1983, AM J PATHOL, V110, P83

[4] THE STRUCTURE OF THE HUMAN GLUTATHIONE S-TRANSFERASE PI-GENE [J].